Metabolic Engineering

Metabolic engineering is a bioengineering discipline that systematically designs and implements genetic modifications to cellular metabolic pathways to optimize production of desired molecules.

11.9K

Publications

744.9K

Citations

36K

Authors

4.3K

Institutions

Publications per year

2017–2026

5.5K

Parents

BioengineeringBiological EngineeringBiomolecular EngineeringBiotechnologyChemical Biology

Children

Adaptive Laboratory EvolutionCarbon MetabolismCell Factory DesignCofactor EngineeringCompartmentalization Of Metabolic PathwaysDynamic Metabolic ControlFlux Balance AnalysisGenome-scale Metabolic ModelingMetabolic Burden ReductionMetabolic Pathway Analysis

Publications

11.9K

antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline

Kai Blin, Simon J. Shaw, Kat Steinke et al. · Nucleic Acids Research · 2019 · 3.1K citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +14

Production of the antimalarial drug precursor artemisinic acid in engineered yeast

Dae‐Kyun Ro, Eric M. Paradise, Mario Ouellet et al. · Nature · 2006 · 2.8K citations

Life Sciences, Biological Engineering, Biotechnology +12

Non-fermentative pathways for synthesis of branched-chain higher alcohols as biofuels

Shota Atsumi, Taizo Hanai, James C. Liao · Nature · 2008 · 2K citations

Life Sciences, Biotechnology, Chemical Engineering +14

Flavonoids: biosynthesis, biological functions, and biotechnological applications

Marı́a Lorena Falcone Ferreyra, Sebastián P. Rius, Paula Casati · Frontiers in Plant Science · 2012 · 1.8K citations · Full text

Agriculture, Biotechnology, Plant Sciences +17

Engineering a mevalonate pathway in Escherichia coli for production of terpenoids

Vincent J. J. Martin, Douglas J. Pitera, Sydnor T. Withers et al. · Nature Biotechnology · 2003 · 1.7K citations

Life Sciences, Biotechnology, Microbiology +14

1–5 of 11.9K

Authors

36K

JN
Jens Nielsen
Chalmers University of Technology, Sweden
144 publications · 15.2K citations
73
h-index
JD
Jay D. Keasling
University of California, Berkeley, United States
137 publications · 22.4K citations
72
h-index
SY
Sang Yup Lee
Korea Advanced Institute of Science and Technology, South Korea
166 publications · 19.1K citations
70
h-index
GS
Gregory Stephanopoulos
Massachusetts Institute of Technology, United States
78 publications · 13.7K citations
52
h-index
GD
Guocheng Du
Jiangnan University, China
114 publications · 6.1K citations
46
h-index

1–5 of 36K

Institutions

4.3K

1–8 of 4.3K

Venues

Metabolic Engineering
724 publications · 69.6K citations
140
h-index
Applied and Environmental Microbiology
AEM · 466 publications · 43.7K citations
122
h-index
Biotechnology and Bioengineering
606 publications · 41.8K citations
107
h-index
Proceedings of the National Academy of Sciences
PNAS · 156 publications · 26.6K citations
93
h-index
Microbial Cell Factories
580 publications · 34.9K citations
93
h-index

1–5

See also Metabolic Engineering
Core Methods	Synthetic Biology Pathway Engineering Protein Engineering Metabolic Pathway Analysis Flux Balance Analysis Metabolic Control Analysis Optogenetics Systems Metabolic Engineering Genome-scale Metabolic Modeling Gene Knockout Dynamic Metabolic Control Gene Overexpression Constraint-based Modeling Gene Insertion Regression Surrogates Recombinant Dna Technology Heterologous Pathway Integration
Applications	Drug Design Renewable Energy Biofuels
Evaluation	Theoretical Yield
Limitations	Enzyme Kinetics
Modeling Tools	Metabolic Pathway Analysis Genome-scale Metabolic Modeling Linear Programming Constraint-based Modeling