Concepedia

Constraint-based Modeling

Constraint-Based Modeling is a mathematical modeling framework in computational systems biology that represents biological networks as systems of physico-chemical and physiological constraints on reaction fluxes or states and infers their feasible or optimal behaviors without requiring detailed kinetic parameters.

841

Publications

72.3K

Citations

2.3K

Authors

911

Institutions

Publications per year

2017–2026

212

Parents

Children

Publications

841

LINCS: A linear constraint solver for molecular simulations

Berk Hess, Henk Bekker, Herman J. C. Berendsen et al. · Journal of Computational Chemistry · 1997 · 17.1K citations

, , +14

LINCS: A linear constraint solver for molecular simulations

Berk Hess, Henk Bekker, Herman J. C. Berendsen et al. · Journal of Computational Chemistry · 1997 · 2K citations

, , +14

Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0

Jan Schellenberger, Richard Que, Ronan M. T. Fleming et al. · Nature Protocols · 2011 · 1.9K citations · Full text

, , +17

Models of Hierarchically Constrained Dynamics for Glassy Relaxation

R. G. Palmer, D. L. Stein, Elihu Abrahams et al. · Physical Review Letters · 1984 · 1.5K citations

, , +14

COBRApy: COnstraints-Based Reconstruction and Analysis for Python

Ali Ebrahim, Joshua A. Lerman, Bernhard Ø. Palsson et al. · BMC Systems Biology · 2013 · 1.5K citations · Full text

, , +13

1–5 of 841

Authors

2.3K

  1. BØ
    Bernhard Ø. Palsson

    University of California San Diego, United States

    16 publications · 6.7K citations

    16

    h-index

  2. IT
    Ines Thiele

    University of Luxembourg, Luxembourg

    13 publications · 4.3K citations

    13

    h-index

  3. SK
    Steffen Klamt

    Max Planck Institute for Dynamics of Complex Technical Systems, Germany

    12 publications · 763 citations

    12

    h-index

  4. AB
    Alexander Bockmayr

    Freie Universität Berlin, Germany

    10 publications · 374 citations

    10

    h-index

  5. JL
    Jennifer L. Reed

    University of Wisconsin–Madison, United States

    9 publications · 739 citations

    9

    h-index

1–5 of 2.3K

Institutions

911

  1. Centre National de la Recherche Scientifique

    Paris, France

    21 h-index

    89 publications

    3.3K citations

  2. University of California San Diego

    San Diego, United States

    19 h-index

    75 publications

    41.9K citations

  3. Technical University of Denmark

    Kongens Lyngby, Denmark

    15 h-index

    27 publications

    3.7K citations

  4. Novo Nordisk Foundation

    Copenhagen, Denmark

    14 h-index

    20 publications

    3.5K citations

  5. University of Wisconsin–Madison

    Madison, United States

    13 h-index

    27 publications

    1.5K citations

  6. California Institute of Technology

    Pasadena, United States

    13 h-index

    21 publications

    4.3K citations

  7. University of California, Berkeley

    Berkeley, United States

    13 h-index

    25 publications

    1.2K citations

  8. Stanford University

    Stanford, United States

    13 h-index

    28 publications

    4K citations

1–8 of 911

Venues

  1. Bioinformatics

    33 publications · 1.9K citations

    22

    h-index

  2. PLoS Computational Biology

    25 publications · 1.8K citations

    21

    h-index

  3. BMC Systems Biology

    22 publications · 2.9K citations

    19

    h-index

  4. Computers & Chemical Engineering

    14 publications · 859 citations

    14

    h-index

  5. PLoS ONE

    16 publications · 747 citations

    13

    h-index

1–5