Dynamic Metabolic Control

Dynamic Metabolic Control is a metabolic engineering strategy that employs genetically encoded regulatory circuits to modulate pathway gene expression and metabolic fluxes in a time- or state-dependent manner in response to internal and/or external signals, thereby enabling autonomous and adaptive optimization of cellular production.

246

Publications

14.9K

Citations

999

Authors

389

Institutions

Publications per year

2017–2026

115

Parents

Metabolic Engineering

Children

Control Of Precursor SupplyDynamic BiosensorsDynamic Pathway BalancingEnzyme Degradation TagsEnzyme Expression TuningFeedforward Control CircuitsMetabolite-responsive PromotersOptogenetic Control Of MetabolismOscillatory Control CircuitsPost-translational Control Of Metabolism

Publications

246

Metabolic control theory: A structural approach

Christine Reder · Journal of Theoretical Biology · 1988 · 563 citations

Life Sciences, Physiology, Bioenergetics +13

Phospholipid Metabolism Regulated by a Transcription Factor Sensing Phosphatidic Acid

Christopher Loewen, María L. Gaspar, Stephen A. Jesch et al. · Science · 2004 · 509 citations

Life Sciences, Biochemistry, Molecular Biology +17

Improving fatty acids production by engineering dynamic pathway regulation and metabolic control

Peng Xu, Lingyun Li, Fuming Zhang et al. · Proceedings of the National Academy of Sciences · 2014 · 496 citations · Full text

Engineering, Bioengineering, Biotechnology +17

Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

Sergio Gascón, Elisa Murenu, Giacomo Masserdotti et al. · Cell stem cell · 2015 · 366 citations · Full text

Medicine, Neurobiology, Neuroscience +16

Sterol regulatory element binding protein 1 couples mechanical cues and lipid metabolism

Rebecca Bertolio, Francesco Napoletano, Miguel Mano et al. · Nature Communications · 2019 · 299 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

1–5 of 246

Authors

999

GD
Guocheng Du
Jiangnan University, China
10 publications · 844 citations
10
h-index
LL
Long Liu
Jiangnan University, China
9 publications · 819 citations
9
h-index
JL
Jianghua Li
Jiangnan University, China
9 publications · 819 citations
9
h-index
YL
Yanfeng Liu
Jiangnan University, China
8 publications · 681 citations
8
h-index
HV
Hans V. Westerhoff
University of Amsterdam, Netherlands
7 publications · 191 citations
7
h-index

1–5 of 999

Institutions

389

1–8 of 389

Venues

ACS Synthetic Biology
25 publications · 1.4K citations
21
h-index
Nature Communications
21 publications · 1.9K citations
19
h-index
Metabolic Engineering
15 publications · 1.1K citations
15
h-index
Biotechnology and Bioengineering
10 publications · 396 citations
10
h-index
Journal of Theoretical Biology
9 publications · 919 citations
9
h-index

1–5