RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10

RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory

Sylvain Lesné, Ming Teng Koh, Linda Kotilinek et al. · Nature · 2006 · 2.8K citations

Life Sciences, Neurobiology, Neuroscience +16

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Jill C. Milne, Philip Lambert, Simon Schenk et al. · Nature · 2007 · 1.7K citations · Full text

Medicine, Medicinal Chemistry, Molecular Biology +14

Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: evidence for augmentation of a 42-specific γ secretase

Joanna L. Jankowsky, Daniel J. Fadale, Jeffrey C. Anderson et al. · Human Molecular Genetics · 2003 · 1.6K citations · Full text

Life Sciences, Neurology, Neuroscience +16

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

David Borchelt, Gopal Thinakaran, Christopher B. Eckman et al. · Neuron · 1996 · 1.5K citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

Hwei-Ling Cheng, Raúl Mostoslavsky, Shinichi Saito et al. · Proceedings of the National Academy of Sciences · 2003 · 1.1K citations · Full text

Life Sciences, Genetics, Molecular Biology +17