A Significant Role of Human Cytochrome P450 2C8 in Amiodarone N-Deethylation: An Approach to Predict the Contribution with Relative Activity Factor

Reactions and significance of cytochrome P-450 enzymes

F. Peter Guengerich · Journal of Biological Chemistry · 1991 · 603 citations · Full text

Life Sciences, Biochemistry, Enzyme Mechanism +16

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

Raimund M. Peter, Ronald Boecker, Philippe Beaune et al. · Chemical Research in Toxicology · 1990 · 535 citations

Medicine, Pharmacology, Toxicology +11

Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8.

Atiqur Rahman, Ken Korzekwa, James Grogan et al. · PubMed · 1994 · 391 citations

Medicine, Biochemistry, Pharmacology +17

Identification of an inducible form of cytochrome P-450 in human liver.

Paul B. Watkins, Steven Wrighton, Patrick Maurel et al. · Proceedings of the National Academy of Sciences · 1985 · 323 citations · Full text

Medicine, Pharmacology, Biochemical Pharmacology +15

Development of a Substrate-Activity Based Approach To Identify the Major Human Liver P-450 Catalysts of Cyclophosphamide and Ifosfamide Activation Based on cDNA-Expressed Activities and Liver Microsomal P-450 Profiles

Partha Pratim Roy, L J Yu, Charles L. Crespi et al. · Drug Metabolism and Disposition · 1999 · 319 citations

Medicine, Biochemistry, Pharmacology +17