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Vorinostat synergizes with EGFR inhibitors in NSCLC cells by increasing ROS via up-regulation of the major mitochondrial porin VDAC1 and modulation of the c-Myc-NRF2-KEAP1 pathway

C-myc-nrf2-keap1 PathwaySignal TransductionSignaling PathwayMitochondrial FunctionMedicineReceptor Tyrosine KinaseNsclc CellsEgfr InhibitorsPharmacologyCell BiologyCell Signaling