Chiara Ciardiello

Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles

Valentina R. Minciacchi, Sungyong You, Cristiana Spinelli et al. · Oncotarget · 2015 · 386 citations · Full text

Large oncosomes overexpressing integrin alpha-V promote prostate cancer adhesion and invasion via AKT activation

Chiara Ciardiello, Alessandra Leone, Paola Lanuti et al. · Journal of Experimental & Clinical Cancer Research · 2019 · 117 citations · Full text

Inhibition of autophagy by chloroquine prevents resistance to PI3K/AKT inhibitors and potentiates their antitumor effect in combination with paclitaxel in triple negative breast cancer models

Stefania Cocco, Alessandra Leone, Maria Serena Roca et al. · Journal of Translational Medicine · 2022 · 109 citations · Full text

Vorinostat synergizes with EGFR inhibitors in NSCLC cells by increasing ROS via up-regulation of the major mitochondrial porin VDAC1 and modulation of the c-Myc-NRF2-KEAP1 pathway

Alessandra Leone, Maria Serena Roca, Chiara Ciardiello et al. · Free Radical Biology and Medicine · 2015 · 82 citations

C-myc-nrf2-keap1 Pathway, Signal Transduction, Signaling Pathway +8

Synergistic antitumor interaction of valproic acid and simvastatin sensitizes prostate cancer to docetaxel by targeting CSCs compartment via YAP inhibition

Federica Iannelli, Maria Serena Roca, Rita Lombardi et al. · Journal of Experimental & Clinical Cancer Research · 2020 · 56 citations · Full text