A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

Sreenath V. Sharma, Diana Lee, Bihua Li, +13

Cell

ChromatinChromatin RemodelingMedicineCancer Cell BiologyCancer Cell Subpopulations +4

Systematic identification of genomic markers of drug sensitivity in cancer cells

Mathew J. Garnett, Elena J. Edelman, Sonja J. Heidorn, +51

Nature

Systematic IdentificationGenomic MarkersEngineeringTumor HeterogeneityMedicine +10

Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib

Eunice L. Kwak, Raffaella Sordella, Daphne W. Bell, +14

Proceedings of the National Academy of Sciences

Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR

Daphne W. Bell, Ira Gore, Ross A. Okimoto, +8

Nature Genetics

Tumor BiologySomatic VariantMedicineGeneticsPathology +7

Elevated CRAF as a Potential Mechanism of Acquired Resistance to BRAF Inhibition in Melanoma

Clara Montagut, Sreenath V. Sharma, Toshi Shioda, +10

Cancer Research

Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling

Ultan McDermott, Sreenath V. Sharma, Lori Dowell, +22

Proceedings of the National Academy of Sciences

EngineeringKinase InhibitorsCancer BiologyTumor BiologyTumor Heterogeneity +16

Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol

Sreenath V. Sharma, Tsutomu Agatsuma, Hirofumi Nakano

Oncogene

Protein FunctionBiochemistryNatural SciencesProtein ChaperoneMolecular Biology +3

A common signaling cascade may underlie “addiction” to the Src, BCR-ABL, and EGF receptor oncogenes

Sreenath V. Sharma, Patrycja Gajowniczek, Inna P. Way, +6

Cancer Cell

Signal TransductionSignaling PathwayAddictionMedicineReceptor Tyrosine Kinase +8

A Phase I Study of Erlotinib and Hydroxychloroquine in Advanced Non–Small-Cell Lung Cancer

Sarah B. Goldberg, Jeffrey G. Supko, Joel W. Neal, +11

Journal of Thoracic Oncology

OncologyMedicineAnti-cancer AgentCancer TreatmentPharmacology +2

Inhibition of γ-Secretase Activity Inhibits Tumor Progression in a Mouse Model of Pancreatic Ductal Adenocarcinoma

Ruben R. Plentz, Ji–Sun Park, Andrew D. Rhim, +10

Gastroenterology

Tumor BiologyPancreatic CancerMedicinePathologyCancer Biology +6