Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

Wanjuan Yang, Jorge Soares, Patricia Greninger, +14

Nucleic Acids Research

Therapeutic Biomarker DiscoveryDrug TargetEngineeringPathologyTumor Biology +19

Systematic identification of genomic markers of drug sensitivity in cancer cells

Mathew J. Garnett, Elena J. Edelman, Sonja J. Heidorn, +51

Nature

Systematic IdentificationGenomic MarkersEngineeringTumor HeterogeneityMedicine +10

Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer

Anthony C. Faber, Anna F. Farago, Carlotta Costa, +27

Proceedings of the National Academy of Sciences

mTOR Inhibition Specifically Sensitizes Colorectal Cancers with <i>KRAS</i> or <i>BRAF</i> Mutations to BCL-2/BCL-XL Inhibition by Suppressing MCL-1

Anthony C. Faber, Erin M. Coffee, Carlotta Costa, +18

Cancer Discovery

RETRACTED: A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities

Katherine S. Garman, Chaitanya R. Acharya, Elena J. Edelman, +13

Proceedings of the National Academy of Sciences

OncologyTherapeutic OpportunitiesGastrointestinal OncologyCancer RiskMedicine +13

A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration

Gromoslaw A. Smolen, Jianmin Zhang, Matthew Zubrowski, +10

Genes & Development

Epithelial Cell MigrationCancer BiologyTumor BiologyTranscriptional RegulationSignaling Pathway +15

Analysis of sample set enrichment scores: assaying the enrichment of sets of genes for individual samples in genome-wide expression profiles

Elena J. Edelman, Alessandro Porrello, Justin Guinney, +4

Bioinformatics

Modeling Cancer Progression via Pathway Dependencies

Elena J. Edelman, Justin Guinney, Jen‐Tsan Chi, +2

PLoS Computational Biology

Tumor BiologyEngineeringCancer TypesTumor HeterogeneityMedicine +13

Breast tumor progression induced by loss of BTG2 expression is inhibited by targeted therapy with the ErbB/HER inhibitor lapatinib

Fuminori Takahashi, Naokazu Chiba, Ken Tajima, +8

Oncogene

Breast OncologyBreast Tumor ProgressionMedicineBreast CancerCancer Biology +8

Cross-Species Array Comparative Genomic Hybridization Identifies Novel Oncogenic Events in Zebrafish and Human Embryonal Rhabdomyosarcoma

Eleanor Y. Chen, Kimberly P. Dobrinski, Kim H. Brown, +10

PLoS Genetics

GeneticsMolecular GeneticsGenomicsCancer BiologyTumor Biology +17