Concepedia

Nrf2 Pathway Activation

Nrf2 Pathway Activation is a molecular signaling mechanism that, under the genus of cellular stress response pathways, is differentiated by its specific induction of antioxidant and detoxifying gene expression through the translocation of the nuclear factor erythroid 2-related factor 2 (Nrf2) from the cytoplasm to the nucleus in response to oxidative stress or electrophilic stimuli.

7.4K

Publications

484.4K

Citations

40.1K

Authors

4.7K

Institutions

Publications per year

2017–2026

4.8K

Parents

Publications

7.4K

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh et al. · Genes & Development · 1999 · 3.6K citations · Full text

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

Masaaki Komatsu, Satoshi Waguri, Keiko Taguchi et al. · Nature Cell Biology · 2010 · 2.4K citations

, , +14

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Gina M. DeNicola, Florian A. Karreth, Timothy J. Humpton et al. · Nature · 2011 · 2.2K citations · Full text

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Activation of the p62‐Keap1‐NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

Xiaofang Sun, Zhanhui Ou, Ruochan Chen et al. · Hepatology · 2015 · 2K citations · Full text

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Albena T. Dinkova‐Kostova, W. David Holtzclaw, Robert N. Cole et al. · Proceedings of the National Academy of Sciences · 2002 · 1.9K citations · Full text

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1–5 of 7.4K

Authors

40.1K

  1. MY
    Masayuki Yamamoto

    Tohoku University, Japan

    214 publications · 49.6K citations

    106

    h-index

  2. TW
    Thomas W. Kensler

    Johns Hopkins University, United States

    67 publications · 14.4K citations

    52

    h-index

  3. SB
    Shyam Biswal

    Johns Hopkins University, United States

    61 publications · 11.4K citations

    46

    h-index

  4. KI
    Ken Itoh

    Hirosaki University, Japan

    53 publications · 16.7K citations

    42

    h-index

  5. AT
    Ah‐Ng Tony Kong

    Rutgers, The State University of New Jersey, United States

    50 publications · 4.8K citations

    39

    h-index

1–5 of 40.1K

Institutions

4.7K

  1. Johns Hopkins University

    Baltimore, United States

    90 h-index

    738 publications

    165.1K citations

  2. Tohoku University

    Sendai, Japan

    77 h-index

    650 publications

    83.8K citations

  3. University of Tsukuba

    Tsukuba, Japan

    76 h-index

    538 publications

    157.4K citations

  4. Jilin University

    Changchun, China

    59 h-index

    762 publications

    56.9K citations

  5. Johns Hopkins Medicine

    Baltimore, United States

    59 h-index

    282 publications

    36.7K citations

  6. Rutgers, The State University of New Jersey

    New Brunswick, United States

    55 h-index

    398 publications

    40.8K citations

  7. University of Arizona

    Tucson, United States

    52 h-index

    362 publications

    59.2K citations

  8. First Hospital of Jilin University

    Changchun, China

    50 h-index

    432 publications

    39.7K citations

1–8 of 4.7K

Venues

  1. Free Radical Biology and Medicine

    272 publications · 22.4K citations

    85

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  2. Oxidative Medicine and Cellular Longevity

    227 publications · 11.1K citations

    61

    h-index

  3. PLoS ONE

    141 publications · 9.7K citations

    61

    h-index

  4. Redox Biology

    138 publications · 10.6K citations

    60

    h-index

  5. Journal of Biological Chemistry

    JBC · 86 publications · 17.3K citations

    58

    h-index

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