Nobunao Wakabayashi

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh et al. · Genes & Development · 1999 · 3.5K citations · Full text

Lipid Peroxidation, Molecular Biology, Redox Biology +18

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Albena T. Dinkova‐Kostova, W. David Holtzclaw, Robert N. Cole et al. · Proceedings of the National Academy of Sciences · 2002 · 1.9K citations · Full text

Aldo-keto Reductase, Molecular Biology, Thiol Addition +19

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

Nobunao Wakabayashi, Albena T. Dinkova‐Kostova, W. David Holtzclaw et al. · Proceedings of the National Academy of Sciences · 2004 · 959 citations · Full text

Molecular Biology, Redox Biology, Oxidant Stress +19

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

Nobunao Wakabayashi, Ken Itoh, Junko Wakabayashi et al. · Nature Genetics · 2003 · 883 citations

Reductive Stress, Genome Instability, Developmental Biology +9

Keap1 regulates both cytoplasmic‐nuclear shuttling and degradation of Nrf2 in response to electrophiles

Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh et al. · Genes to Cells · 2003 · 818 citations