W. David Holtzclaw

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Albena T. Dinkova‐Kostova, W. David Holtzclaw, Robert N. Cole et al. · Proceedings of the National Academy of Sciences · 2002 · 1.9K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

Nobunao Wakabayashi, Albena T. Dinkova‐Kostova, W. David Holtzclaw et al. · Proceedings of the National Academy of Sciences · 2004 · 966 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress

Albena T. Dinkova‐Kostova, Karen T. Liby, Katherine K. Stephenson et al. · Proceedings of the National Academy of Sciences · 2005 · 566 citations

Life Sciences, Immunology, Pharmacology +17

Chemical and molecular regulation of enzymes that detoxify carcinogens.

Tory Prestera, W. David Holtzclaw, Yuesheng Zhang et al. · Proceedings of the National Academy of Sciences · 1993 · 426 citations

Pharmacy, Biochemistry, Toxicology +17

Safety, Tolerance, and Metabolism of Broccoli Sprout Glucosinolates and Isothiocyanates: A Clinical Phase I Study

Theresa A. Shapiro, Jed W. Fahey, Albena T. Dinkova‐Kostova et al. · Nutrition and Cancer · 2006 · 333 citations

Medicine, Nutrition, Pharmacology +8