W. David Holtzclaw

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Albena T. Dinkova‐Kostova, W. David Holtzclaw, Robert N. Cole et al. · Proceedings of the National Academy of Sciences · 2002 · 1.9K citations · Full text

Aldo-keto Reductase, Molecular Biology, Thiol Addition +19

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

Nobunao Wakabayashi, Albena T. Dinkova‐Kostova, W. David Holtzclaw et al. · Proceedings of the National Academy of Sciences · 2004 · 959 citations · Full text

Molecular Biology, Redox Biology, Oxidant Stress +19

Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress

Albena T. Dinkova‐Kostova, Karen T. Liby, Katherine K. Stephenson et al. · Proceedings of the National Academy of Sciences · 2005 · 560 citations · Full text

Lipid Peroxidation, Cell Death, Potent Triterpenoid Inducers +17

Chemical and molecular regulation of enzymes that detoxify carcinogens.

Tory Prestera, W. David Holtzclaw, Yuesheng Zhang et al. · Proceedings of the National Academy of Sciences · 1993 · 426 citations · Full text

Reductive Stress, Biochemistry, Molecular Regulation +14

Safety, Tolerance, and Metabolism of Broccoli Sprout Glucosinolates and Isothiocyanates: A Clinical Phase I Study

Theresa A. Shapiro, Jed W. Fahey, Albena T. Dinkova‐Kostova et al. · Nutrition and Cancer · 2006 · 328 citations