Three-Dimensional-Quantitative Structure Activity Relationship Analysis of Cytochrome P-450 3A4 Substrates

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

Tsutomu Shimada, Hiroshi Yamazaki, Mayumi Mimura et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 2.8K citations

Characterization of Interintestinal and Intraintestinal Variations in Human CYP3A-Dependent Metabolism

Mary F. Paine, Mehraneh Khalighi, Jeannine M. Fisher et al. · Journal of Pharmacology and Experimental Therapeutics · 1997 · 791 citations

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

F. Peter Guengerich, M V Martin, Philippe Beaune et al. · Journal of Biological Chemistry · 1986 · 730 citations · Full text

Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.

Thomas Kronbach, Daniel Mathys, Makoto Umeno et al. · Molecular Pharmacology · 1989 · 534 citations

Evaluation of Atypical Cytochrome P450 Kinetics with Two-Substrate Models:  Evidence That Multiple Substrates Can Simultaneously Bind to Cytochrome P450 Active Sites

Ken Korzekwa, N. Krishnamachary, Magang Shou et al. · Biochemistry · 1998 · 516 citations