Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

Eiichi Araki, Myra A. Lipes, Mary‐Elizabeth Patti, +4

Nature

Molecular PhysiologySignal TransductionInsulin SignallingSignaling PathwayDiabetes +9

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

Hiroyuki Tamemoto, Takashi Kadowaki, Kazuyuki Tobe, +15

Nature

Insulin ResistanceMetabolic SyndromeInsulin SignalingGrowth HormoneInsulin Receptor Substrate-1 +9

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

Bentley Cheatham, Chris J. Vlahos, Lynn Cheatham, +3

Molecular and Cellular Biology

Phosphatidylinositol 3-KinaseInsulin SignalingPp70 S6 KinaseMetabolic SyndromeReceptor Tyrosine Kinase +18

Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin.

Taro Okada, Y. Kawano, Tsuneki Sakakibara, +2

Journal of Biological Chemistry

Insulin ReceptorInsulin SignalingMolecular PharmacologyMetabolic SyndromeCell Signaling +17

Role of IRS-2 in insulin and cytokine signalling

Xiao Jian Sun, Ling-Mei Wang, Yitao Zhang, +6

Nature

Molecular PhysiologySignal TransductionDiabetesCytokine SignallingMetabolic Regulation +4

Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.

Bentley Cheatham, Chris J. Vlahos, L Cheatham, +3

Molecular and Cellular Biology

Phosphatidylinositol 3-KinaseInsulin SignalingPp70 S6 KinaseMetabolic SyndromeSignaling Pathway +19

Gene Targeting: A Practical Approach

Mark C. Hirst

Journal of Medical Genetics

EngineeringGene TargetingGenetic EngineeringGene DeliveryGene Vector +4

Development of a Novel Polygenic Model of NIDDM in Mice Heterozygous for IR and IRS-1 Null Alleles

Jens C. Brüning, Jonathon N. Winnay, Susan Bonner‐Weir, +3

Cell

Knockout MouseDevelopmental BiologyIrs-1 Null AllelesGeneticsNovel Polygenic Model +8

Apoptosis Participates in the Remodeling of the Endocrine Pancreas in the Neonatal Rat*

Luisa Scaglia, Christopher J. Cahill, Diane T. Finegood, +1

Endocrinology

Joslinʼs Diabetes Mellitus

C. Ronald Kahn, Gordon C. Weir

The Endocrinologist

Diabetes ManagementDiabetesPathologyDiabetes ComplicationsDiabetes Mellitus +1