Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

Jeh-Ping Liu, Julie C. Baker, Archlbald S. Perkins et al. · Cell · 1993 · 2.9K citations

Life Sciences, Developmental Biology, Genetics +16

The insulin signaling system.

Morris F. White, C. Ronald Kahn · Journal of Biological Chemistry · 1994 · 1.7K citations · Full text

Life Sciences, Endocrinology, Molecular Biology +10

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

Xiao‐Jian Sun, Paul Rothenberg, C. Ronald Kahn et al. · Nature · 1991 · 1.6K citations

Life Sciences, Biochemistry, Molecular Biology +14

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

Hiroyuki Tamemoto, Takashi Kadowaki, Kazuyuki Tobe et al. · Nature · 1994 · 1.1K citations

Medicine, Biochemistry, Endocrinology +16

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells

Morris F. White, Ruth Maron, C. Ronald Kahn · Nature · 1985 · 657 citations

Life Sciences, Biochemistry, Molecular Biology +14