Xiao‐Jian Sun

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

Xiao‐Jian Sun, Paul Rothenberg, C. Ronald Kahn et al. · Nature · 1991 · 1.6K citations

Signal Transduction, Molecular Physiology, Biochemistry +9

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

Jonathan Backer, Martin G. Myers, Steven E. Shoelson et al. · The EMBO Journal · 1992 · 1K citations · Full text

Molecular Pharmacology, Insulin Signaling, Molecular Physiology +14

Metformin and Insulin Suppress Hepatic Gluconeogenesis through Phosphorylation of CREB Binding Protein

Ling He, Amin Sabet, Stephen Djedjos et al. · Cell · 2009 · 478 citations · Full text

Metabolic Syndrome, Insulin Signaling, Signal Transduction +13

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85.

Martin G. Myers, Jonathan Backer, Xiao‐Jian Sun et al. · Proceedings of the National Academy of Sciences · 1992 · 476 citations

Molecular Regulation, Irs-1 Activates, Molecular Biology +19

Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

Frédéric Tremblay, Sophie Brûlé, Sung Hee Um et al. · Proceedings of the National Academy of Sciences · 2007 · 458 citations · Full text

Amino Acids, Metabolic Disorder, Obesity-induced Insulin Resistance +19