Concepedia

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

Qing Guo, Weiming Fu, Bryce L. Sopher, Miles W. Miller, Carol B. Ware, George M. Martin, Mark P. Mattson

Nature Medicine · 1999 · 493 citations · 26 references

DOI

Concepts

References

26

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

Grzegorz Grynkiewicz, Martin Poenie, Roger Y. Tsien · Journal of Biological Chemistry · 1985 · 21.7K citations · Full text

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Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Donalyn Scheuner, Christopher B. Eckman, M. Jensen et al. · Nature Medicine · 1996 · 2.6K citations

, , +16

Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

András Nagy, Janet Rossant, Roland Nagy et al. · Proceedings of the National Academy of Sciences · 1993 · 2.4K citations

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beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

MP Mattson, Bin Cheng, David L. Davis et al. · Journal of Neuroscience · 1992 · 1.6K citations · Full text

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Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

David Borchelt, Gopal Thinakaran, Christopher B. Eckman et al. · Neuron · 1996 · 1.5K citations · Full text

, , +17