Bryce L. Sopher

The Werner syndrome protein is a DNA helicase

Matthew D. Gray, Jiang-Cheng Shen, Ashwini S. Kamath‐Loeb et al. · Nature Genetics · 1997 · 612 citations

Life Sciences, Genetics, Molecular Biology +5

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

Qing Guo, Weiming Fu, Bryce L. Sopher et al. · Nature Medicine · 1999 · 493 citations

Life Sciences, Neurobiology, Neuroscience +14

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

Qing Guo, Bryce L. Sopher, Katsutoshi Furukawa et al. · PubMed · 1997 · 482 citations

Life Sciences, Neurobiology, Neuroscience +17

Deficient Neurogenesis in Forebrain-Specific Presenilin-1 Knockout Mice Is Associated with Reduced Clearance of Hippocampal Memory Traces

Ruiben Feng, Claire Rampon, Ya‐Ping Tang et al. · Neuron · 2001 · 469 citations · Full text

Life Sciences, Neurobiology, Neuroscience +16

Alzheimer’s Presenilin Mutation Sensitizes Neural Cells to Apoptosis Induced by Trophic Factor Withdrawal and Amyloid β-Peptide: Involvement of Calcium and Oxyradicals

Qing Guo, Bryce L. Sopher, Katsutoshi Furukawa et al. · Journal of Neuroscience · 1997 · 399 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17