Concepedia

Wnt Ligands

Wnt Ligands is a family of secreted cysteine-rich glycoprotein signaling molecules that act as extracellular ligands to initiate and regulate cell-to-cell communication through the activation of Frizzled receptor-mediated pathways in developmental and homeostatic processes.

794

Publications

71.9K

Citations

5.1K

Authors

1.3K

Institutions

Publications per year

2017–2026

267

Variants

Wnt Proteins

Parents

Publications

794

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

Wim de Lau, Nick Barker, Teck Yew Low et al. · Nature · 2011 · 1.3K citations

, , +9

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

Daniel Pinto, Alex Gregorieff, Harry Begthel et al. · Genes & Development · 2003 · 1K citations · Full text

, , +17

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

Bon‐Kyoung Koo, Maureen Spit, Ingrid Jordens et al. · Nature · 2012 · 995 citations · Full text

, , +16

Structural Basis of Wnt Recognition by Frizzled

Claudia Y. Janda, Deepa Waghray, Aron M. Levin et al. · Science · 2012 · 876 citations

, , +17

R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling

Kendra S. Carmon, Xing Gong, Qiushi Lin et al. · Proceedings of the National Academy of Sciences · 2011 · 857 citations · Full text

, , +17

1–5 of 794

Authors

5.1K

  1. MB
    Michael Boutros

    Heidelberg University, Germany

    11 publications · 1.7K citations

    11

    h-index

  2. XH
    Xi He

    Boston Children's Hospital, United States

    9 publications · 1.6K citations

    9

    h-index

  3. RA
    Richard A. Lang

    Cincinnati Children's Hospital Medical Center, United States

    9 publications · 847 citations

    9

    h-index

  4. HC
    Hans Clevers

    Hubrecht Institute for Developmental Biology and Stem Cell Research, Netherlands

    8 publications · 4.6K citations

    8

    h-index

  5. JN
    Jeremy Nathans

    Johns Hopkins University, United States

    7 publications · 2.6K citations

    7

    h-index

1–5 of 5.1K

Institutions

1.3K

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    38 h-index

    136 publications

    41.2K citations

  2. Harvard University

    Cambridge, United States

    26 h-index

    95 publications

    16.1K citations

  3. Stanford University

    Stanford, United States

    24 h-index

    102 publications

    19.1K citations

  4. Heidelberg University

    Heidelberg, Germany

    23 h-index

    134 publications

    14.3K citations

  5. German Cancer Research Center

    Heidelberg, Germany

    18 h-index

    77 publications

    10.6K citations

  6. University of Pennsylvania

    Philadelphia, United States

    18 h-index

    97 publications

    6.3K citations

  7. Boston Children's Hospital

    Boston, United States

    17 h-index

    49 publications

    5.6K citations

  8. National Institutes of Health

    Bethesda, United States

    16 h-index

    62 publications

    10K citations

1–8 of 1.3K

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 34 publications · 7.1K citations

    32

    h-index

  2. Journal of Biological Chemistry

    JBC · 39 publications · 4.4K citations

    29

    h-index

  3. Development

    35 publications · 3.4K citations

    28

    h-index

  4. PLoS ONE

    36 publications · 1.9K citations

    25

    h-index

  5. eLife

    15 publications · 1.4K citations

    15

    h-index

1–5