Concepedia

Reductive Bioactivation

Reductive Bioactivation is a type of metabolic activation process in which a biologically inert compound is converted into an active pharmacological agent through reductive reactions mediated by enzymatic or chemical reduction within biological systems.

35

Publications

1.8K

Citations

135

Authors

55

Institutions

Publications per year

2017–2026

2

Parents

Publications

35

The three-dimensional structure of NAD(P)H:quinone reductase, a flavoprotein involved in cancer chemoprotection and chemotherapy: mechanism of the two-electron reduction.

R Li, Mario A. Bianchet, Paul Talalay et al. · Proceedings of the National Academy of Sciences · 1995 · 336 citations · Full text

, , +15

The Role of NAD(P)H: Quinone Reductase (EC 1.6.99.2, DT-Diaphorase) in the Reductive Bioactivation of the Novel Indoloquinone Antitumor Agent E09

Michael I. Walton, Paul J. Smith, Paul Workman · Cancer Communications · 1991 · 122 citations

, , +17

Nitric oxide synthases catalyze the activation of redox cycling and bioreductive anticancer agents.

Andrew P. Garner, Mark J. I. Paine, Ignacio Rodríguez‐Crespo et al. · PubMed · 1999 · 109 citations

, , +17

NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations

Andrea Gaedigk, Rachel F. Tyndale, Mallé Jurima‐Romet et al. · Pharmacogenetics · 1998 · 101 citations

, , +14

Comparison of the Bioactivation Potential of the Antidepressant and Hepatotoxin Nefazodone with Aripiprazole, a Structural Analog and Marketed Drug

Jonathan Bauman, Kosea S. Frederick, Aarti Sawant et al. · Drug Metabolism and Disposition · 2008 · 83 citations

, , +17

1–5 of 35

Authors

135

  1. MI
    Michael I. Walton

    Institute of Cancer Research, United Kingdom

    4 publications · 341 citations

    4

    h-index

  2. PW
    Paul Workman

    Institute of Cancer Research, United Kingdom

    4 publications · 341 citations

    4

    h-index

  3. NV
    Nico Vermeulen

    Vrije Universiteit Amsterdam, Netherlands

    3 publications · 124 citations

    3

    h-index

  4. CR
    C. Roland Wolf

    Ninewells Hospital, United Kingdom

    3 publications · 259 citations

    3

    h-index

  5. AR
    Arnold R. Goeptar

    Society of Environmental Toxicology and Chemistry, United States

    3 publications · 124 citations

    3

    h-index

1–5 of 135

Institutions

55

  1. MRC Cancer Unit

    Cambridge, United Kingdom

    4 h-index

    7 publications

    560 citations

  2. Vrije Universiteit Amsterdam

    Amsterdam, The Netherlands

    3 h-index

    10 publications

    435 citations

  3. Society of Environmental Toxicology and Chemistry

    Washington, United States

    2 h-index

    3 publications

    134 citations

  4. University of Toronto

    Toronto, Canada

    2 h-index

    3 publications

    241 citations

  5. National Cancer Institute

    Bethesda, United States

    2 h-index

    2 publications

    80 citations

  6. University of Washington

    Seattle, United States

    2 h-index

    8 publications

    314 citations

  7. Max Planck Institute for Medical Research

    Heidelberg, Germany

    1 h-index

    1 publications

    26 citations

  8. Laboratoire d'innovation moléculaire et applications

    Strasbourg, France

    1 h-index

    5 publications

    130 citations

1–8 of 55

Venues

  1. PubMed

    Repository · 6 publications · 312 citations

    6

    h-index

  2. Chemical Research in Toxicology

    5 publications · 138 citations

    5

    h-index

  3. Drug Metabolism and Disposition

    3 publications · 174 citations

    3

    h-index

  4. Biochemical Pharmacology

    3 publications · 177 citations

    3

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 2 publications · 382 citations

    2

    h-index

1–5