Concepedia

Reactive Metabolites

Reactive Metabolites is a class of chemically reactive metabolic intermediates generated during the biotransformation of endogenous compounds or xenobiotics that, by virtue of their electrophilic or redox-active properties, can covalently or oxidatively modify cellular macromolecules and thereby initiate or propagate toxicological injury.

3K

Publications

152.6K

Citations

11.3K

Authors

2.2K

Institutions

Publications per year

2017–2026

432

Parents

Children

Publications

3K

Bromobenzene-Induced Liver Necrosis. Protective Role of Glutathione and Evidence for 3,4-Bromobenzene Oxide as the Hepatotoxic Metabolite

David J. Jollow, John R. Mitchell, Nicola Zampaglione et al. · Pharmacology · 2008 · 3.3K citations

, , +17

ETHOXYRESORUFIN: DIRECT FLUORIMETRIC ASSAY OF A MICROSOMAL O-DEALKYLATION WHICH IS PREFERENTIALLY INDUCIBLE BY 3-METHYLCHOLANTHRENE

M.D. Burke, Richard T. Mayer · Drug Metabolism and Disposition · 1974 · 1.6K citations

, , +17

Phytochemicals: nutraceuticals and human health

Cora J. Dillard, J. Bruce German · Journal of the Science of Food and Agriculture · 2000 · 1.1K citations

, , +17

Formation of a thiobarbituric‐acid‐reactive substance from deoxyribose in the presence of iron salts

Barry Halliwell, John M.C. Gutteridge · FEBS Letters · 1981 · 828 citations · Full text

, , +4

Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes.

Charles N. Serhan, Mats Hámberg, Bengt Samuelsson · Proceedings of the National Academy of Sciences · 1984 · 770 citations · Full text

, , +7

1–5 of 3K

Authors

11.3K

  1. SD
    Sidney D. Nelson

    University of Washington, United States

    23 publications · 1.3K citations

    20

    h-index

  2. RP
    Ronald P. Mason

    National Institute of Environmental Health Sciences, United States

    18 publications · 1.1K citations

    17

    h-index

  3. TA
    Thomas A. Baillie

    University of Washington, United States

    19 publications · 1.3K citations

    17

    h-index

  4. JU
    Jack Uetrecht

    University of Toronto, Canada

    17 publications · 1.1K citations

    17

    h-index

  5. PM
    Patrick M. Dansette

    Centre National de la Recherche Scientifique, France

    18 publications · 1.1K citations

    15

    h-index

1–5 of 11.3K

Institutions

2.2K

  1. University of Washington

    Seattle, United States

    34 h-index

    218 publications

    13.7K citations

  2. National Institutes of Health

    Bethesda, United States

    33 h-index

    173 publications

    12.1K citations

  3. Vanderbilt University

    Nashville, United States

    31 h-index

    154 publications

    14.1K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    28 h-index

    219 publications

    13.6K citations

  5. University of Toronto

    Toronto, Canada

    27 h-index

    69 publications

    4.1K citations

  6. University of Liverpool

    Liverpool, United Kingdom

    21 h-index

    103 publications

    5.7K citations

  7. Pfizer (United States)

    New York, United States

    21 h-index

    153 publications

    5.4K citations

  8. National Institute of Environmental Health Sciences

    Durham, United States

    20 h-index

    77 publications

    6.9K citations

1–8 of 2.2K

Venues

  1. Chemical Research in Toxicology

    203 publications · 10.9K citations

    55

    h-index

  2. PubMed

    Repository · 166 publications · 8K citations

    51

    h-index

  3. Drug Metabolism and Disposition

    145 publications · 7.8K citations

    44

    h-index

  4. Journal of Biological Chemistry

    JBC · 44 publications · 4.5K citations

    38

    h-index

  5. Biochemical Pharmacology

    69 publications · 3.7K citations

    36

    h-index

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