Concepedia

Bioactivation Pathways

Bioactivation Pathways is a metabolic process whereby xenobiotics are enzymatically transformed into reactive metabolites capable of interacting with cellular macromolecules, thereby initiating potential toxicological outcomes.

268

Publications

10.5K

Citations

1.2K

Authors

350

Institutions

Publications per year

2017–2026

53

Parents

Publications

268

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

Ping Wei, Jun Zhang, Margarete Egan-Hafley et al. · Nature · 2000 · 649 citations

, , +13

Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes.

Ricarda Thier, J B Taylor, Sally Pemble et al. · Proceedings of the National Academy of Sciences · 1993 · 189 citations · Full text

, , +17

Bioactivation of tegafur to 5-fluorouracil is catalyzed by cytochrome P-450 2A6 in human liver microsomes in vitro.

Kazumasa Ikeda, Kunihiro Yoshisue, Eiji Matsushima et al. · PubMed · 2000 · 166 citations

, , +17

Decreased glucuronidation and increased bioactivation of acetaminophen in Gilbert's syndrome

Sonia M. F. de Morais, Jack Uetrecht, Peter G. Wells · Gastroenterology · 1992 · 159 citations · Full text

, , +3

Genetic Variations in Human Glutathione Transferase Enzymes: Significance for Pharmacology and Toxicology

P. David Josephy · Human Genomics and Proteomics · 2010 · 158 citations · Full text

, , +14

1–5 of 268

Authors

1.2K

  1. AA
    Adnan A. Kadi

    King Saud University, Saudi Arabia

    12 publications · 366 citations

    12

    h-index

  2. MW
    Mohamed W. Attwa

    King Saud University, Saudi Arabia

    12 publications · 366 citations

    12

    h-index

  3. XD
    Xinxin Ding

    New York State Department of Health, United States

    8 publications · 245 citations

    8

    h-index

  4. HW
    Hany W. Darwish

    King Saud University, Saudi Arabia

    7 publications · 204 citations

    7

    h-index

  5. AS
    Amit S. Kalgutkar

    Pfizer (United States), United States

    7 publications · 432 citations

    7

    h-index

1–5 of 1.2K

Institutions

350

  1. Pfizer (United States)

    New York, United States

    13 h-index

    60 publications

    3.2K citations

  2. King Saud University

    Riyadh, Saudi Arabia

    12 h-index

    43 publications

    1.3K citations

  3. University of Toronto

    Toronto, Canada

    9 h-index

    29 publications

    1.3K citations

  4. University of Minnesota

    Minneapolis, United States

    7 h-index

    19 publications

    589 citations

  5. New York State Department of Health

    Albany, United States

    7 h-index

    27 publications

    1.1K citations

  6. Cairo University

    Giza, Egypt

    7 h-index

    12 publications

    332 citations

  7. University of Arizona

    Tucson, United States

    7 h-index

    25 publications

    532 citations

  8. Riyadh Elm University

    Riyadh, Saudi Arabia

    6 h-index

    23 publications

    714 citations

1–8 of 350

Venues

  1. Chemical Research in Toxicology

    48 publications · 1.9K citations

    29

    h-index

  2. Drug Metabolism and Disposition

    37 publications · 1.2K citations

    22

    h-index

  3. PubMed

    Repository · 14 publications · 682 citations

    13

    h-index

  4. 10

    h-index

  5. RSC Advances

    7 publications · 221 citations

    7

    h-index

1–5