Eiji Matsushima

Bioactivation of tegafur to 5-fluorouracil is catalyzed by cytochrome P-450 2A6 in human liver microsomes in vitro.

Kazumasa Ikeda, Kunihiro Yoshisue, Eiji Matsushima et al. · PubMed · 2000 · 166 citations

Medicine, Biochemistry, Pharmacology +17

Pressure and Temperature Control of Product Chirality in Asymmetric Photochemistry. Enantiodifferentiating Photoisomerization of Cyclooctene Sensitized by Chiral Benzenepolycarboxylates

Yoshihisa Inoue, Eiji Matsushima, Takehiko Wada · Journal of the American Chemical Society · 1998 · 103 citations

Natural Sciences, Chemical Engineering, Chemistry +15

Determination of S-1 (combined drug of tegafur, 5-chloro-2,4- dihydroxypyridine and potassium oxonate and 5-fluorouracil in human plasma and urine using high-performance liquid chromatography and gas chromatography-negative ion chemical ionization mass spectrometry

Eiji Matsushima, Kozo Yoshida, Ryuichi Kitamura et al. · Journal of Chromatography B Biomedical Sciences and Applications · 1997 · 91 citations

Pharmacy, Pharmaceutical Analysis, Pharmacology +17

Enhancement of the antitumour activity of 5-fluorouracil (5-FU) by inhibiting dihydropyrimidine dehydrogenase activity (DPD) using 5-chloro-2,4-dihydroxypyridine (CDHP) in human tumour cells

Teiji Takechi, A Fujioka, Eiji Matsushima et al. · European Journal of Cancer · 2002 · 86 citations

Medicine, Oncology, Pharmacology +14

First-in-human, phase I dose-escalation study of single and multiple doses of a first-in-class enhancer of fluoropyrimidines, a dUTPase inhibitor (TAS-114) in healthy male volunteers

Kaku Saito, Hirotaka Nagashima, Kunihiro Yoshisue et al. · Cancer Chemotherapy and Pharmacology · 2014 · 34 citations

Medicine, Pharmacokinetics, Pharmacology +9