Kunihiro Yoshisue

Bioactivation of tegafur to 5-fluorouracil is catalyzed by cytochrome P-450 2A6 in human liver microsomes in vitro.

Kazumasa Ikeda, Kunihiro Yoshisue, Eiji Matsushima et al. · PubMed · 2000 · 165 citations

Chemical Biology, Toxicological Mechanism, Medicinal Chemistry +16

The Quantitative Prediction of CYP-mediated Drug Interaction by Physiologically Based Pharmacokinetic Modeling

Motohiro Kato, Yoshihisa Shitara, Hitoshi Sato et al. · Pharmaceutical Research · 2008 · 110 citations

Physiologically Based Pharmacokinetics, Pharmacokinetic Modeling, Pharmacological Study +10

Simultaneous Expression of Guinea Pig UDP-Glucuronosyltransferase 2B21 and 2B22 in COS-7 Cells enhances UDP-Glucuronosyltransferase 2B21-Catalyzed Morphine-6-Glucuronide Formation

Yuji Ishii, Aya Miyoshi, Ryoichi Watanabe et al. · Molecular Pharmacology · 2001 · 69 citations

First-in-human, phase I dose-escalation study of single and multiple doses of a first-in-class enhancer of fluoropyrimidines, a dUTPase inhibitor (TAS-114) in healthy male volunteers

Kaku Saito, Hirotaka Nagashima, Kunihiro Yoshisue et al. · Cancer Chemotherapy and Pharmacology · 2014 · 34 citations

Therapeutic Drug Monitoring, Multiple Doses, Healthy Male Volunteers +5

Tissue Distribution and Biotransformation of Potassium Oxonate after Oral Administration of a Novel Antitumor Agent (Drug Combination of Tegafur, 5-Chloro-2,4-dihydroxypyridine, and Potassium Oxonate) to Rats

Kunihiro Yoshisue, Hirotoshi MASUDA, Eiji Matsushima et al. · Drug Metabolism and Disposition · 2000 · 34 citations