Concepedia

Author

Kunihiro Yoshisue

Taiho Pharmaceutical (Japan)

Also Known As

K Yoshisue, K. Yoshisue, Kunihiro YOSHISUE, Kunihiro Yoshisue

57

Publications

703

Citations

14

H-Index

46

Concepts

All Affiliations

Taiho Pharmaceutical (Japan)Kyushu UniversityKanazawa University
KY

About

Kunihiro Yoshisue is an author at Taiho Pharmaceutical (Japan) specializing in pharmacology, medicine, and biochemistry.

Top Concepts

#ConceptH-IndexPublicationsCitations

1

Medicine

9

9

430

2

Biochemistry

5

5

252

3

Cell Biology

3

3

56

4

Natural Sciences

2

2

179

5

Health Sciences

1

1

10

Kunihiro Yoshisue

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17

Publications

651

Citations

14

H-Index

YearCitations

Bioactivation of tegafur to 5-fluorouracil is catalyzed by cytochrome P-450 2A6 in human liver microsomes in vitro.

Kazumasa Ikeda, Kunihiro Yoshisue, Eiji Matsushima,

PubMed

2000

165

The Quantitative Prediction of CYP-mediated Drug Interaction by Physiologically Based Pharmacokinetic Modeling

Motohiro Kato, Yoshihisa Shitara, Hitoshi Sato,

Pharmaceutical Research

2008

110

Simultaneous Expression of Guinea Pig UDP-Glucuronosyltransferase 2B21 and 2B22 in COS-7 Cells enhances UDP-Glucuronosyltransferase 2B21-Catalyzed Morphine-6-Glucuronide Formation

Yuji Ishii, Aya Miyoshi, Ryoichi Watanabe,

Molecular Pharmacology

2001

69

First-in-human, phase I dose-escalation study of single and multiple doses of a first-in-class enhancer of fluoropyrimidines, a dUTPase inhibitor (TAS-114) in healthy male volunteers

Kaku Saito, Hirotaka Nagashima, Kunihiro Yoshisue,

Cancer Chemotherapy and Pharmacology

2014

34

Tissue Distribution and Biotransformation of Potassium Oxonate after Oral Administration of a Novel Antitumor Agent (Drug Combination of Tegafur, 5-Chloro-2,4-dihydroxypyridine, and Potassium Oxonate) to Rats

Kunihiro Yoshisue, Hirotoshi MASUDA, Eiji Matsushima,

Drug Metabolism and Disposition

2000

34

Purification of a Phenobarbital-Inducible UDP-Glucuronosyltransferase Isoform from Dog Liver Which Catalyzes Morphine and Testosterone Glucuronidation

Kazuta Oguri, Akiko Kurogi, Kou-ichi Yamabe,

Archives of Biochemistry and Biophysics

1996

29

TAS-114, a First-in-Class Dual dUTPase/DPD Inhibitor, Demonstrates Potential to Improve Therapeutic Efficacy of Fluoropyrimidine-Based Chemotherapy

Wakako Yano, Tatsushi Yokogawa, Takeshi Wakasa,

Molecular Cancer Therapeutics

2018

29

Effects of 5-Fluorouracil on the Drug-Metabolizing Enzymes of the Small Intestine and the Consequent Drug Interaction with Nifedipine in Rats

Kunihiro Yoshisue, Sekio Nagayama, Takashi Shindo,

Journal of Pharmacology and Experimental Therapeutics

2001

28

Reduction of 5-fluorouracil (5-FU) gastrointestinal (GI) toxicity resulting from the protection of thymidylate synthase (TS) in GI tissue by repeated simultaneous administration of potassium oxonate (Oxo) in rats

Kunihiro Yoshisue, Kazue Hironaga, Syuji Yamaguchi,

Cancer Chemotherapy and Pharmacology

2000

26

Exposure-dependent incorporation of trifluridine into DNA of tumors and white blood cells in tumor-bearing mouse

Fumiaki Yamashita, Ikumi Komoto, Hiroaki Oka,

Cancer Chemotherapy and Pharmacology

2015

24

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