Sidney D. Nelson

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.

David C. Dahlin, Gerald T. Miwa, Albert Lu et al. · Proceedings of the National Academy of Sciences · 1984 · 1.1K citations

Medicine, Pharmacology, Toxicology +16

The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.

Matthew D. Moore, Hjördis Thor, Gregory Moore et al. · Journal of Biological Chemistry · 1985 · 411 citations · Full text

Pharmacy, Pharmacology, Toxicology +17

Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a nonhepatotoxic regioisomer, 3′-hydroxyacetanilide, in mouse liver

Mark A. Tirmenstein, Sidney D. Nelson · Journal of Biological Chemistry · 1989 · 295 citations · Full text

Pharmacy, Pharmacology, Toxicology +17

Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by Human CYP3A4

Kenneth E. Thummel, Caroline A. Lee, Kent L. Kunze et al. · Biochemical Pharmacology · 1993 · 294 citations

Medicine, Pharmacology, Drug Metabolism +7

Isoniazid and Iproniazid: Activation of Metabolites to Toxic Intermediates in Man and Rat

Sidney D. Nelson, J.R. Mitchell, John A. Timbrell et al. · Science · 1976 · 230 citations

Medicine, Biochemistry, Pharmacology +17