Puma Function is a pro-apoptotic signaling construct in the Bcl-2 family protein regulatory network that specifically mediates mitochondrial apoptosis initiation through p53-dependent and p53-independent activation of Bax/Bak oligomerization.
305
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28.7K
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514
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Publications per year
2017–2026
65
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Publications
305
PUMA, a Novel Proapoptotic Gene, Is Induced by p53
Katsunori Nakano, Karen H. Vousden · Molecular Cell · 2001 · 2.3K citations · Full text
p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa
Andreas Villunger, Ewa M. Michalak, Leigh Coultas et al. · Science · 2003 · 1.3K citations
Apoptosis Initiated When BH3 Ligands Engage Multiple Bcl-2 Homologs, Not Bax or Bak
Simon N. Willis, Jamie I. Fletcher, Thomas Kaufmann et al. · Science · 2007 · 1.1K citations
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
John Jeffers, Evan Parganas, Youngsoo Lee et al. · Cancer Cell · 2003 · 872 citations · Full text
Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis
Hyungjin Kim, Ho-Chou Tu, Decheng Ren et al. · Molecular Cell · 2009 · 579 citations · Full text
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- LZ
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- ASAndreas Strasser
Walter and Eliza Hall Institute of Medical Research, Australia
23 publications · 4.6K citations
22
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- AV
12
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- GPGerard P. Zambetti
St. Jude Children's Research Hospital, United States
11 publications · 3.2K citations
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UPMC Hillman Cancer Center
Pittsburgh, United States
28 h-index
116 publications
13.7K citations
Walter and Eliza Hall Institute of Medical Research
Melbourne, Australia
24 h-index
161 publications
39.6K citations
University of Pittsburgh
Pittsburgh, United States
17 h-index
50 publications
5.4K citations
St. Jude Children's Research Hospital
Memphis, United States
15 h-index
51 publications
17.2K citations
The University of Melbourne
Melbourne, Australia
14 h-index
65 publications
19.7K citations
Innsbruck Medical University
Innsbruck, Austria
11 h-index
28 publications
4.7K citations
Royal College of Surgeons in Ireland
Dublin, Ireland
8 h-index
38 publications
2.2K citations
Qingdao University
Qingdao, China
8 h-index
38 publications
858 citations
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Venues
- Journal of Biological Chemistry
JBC · 10 publications · 1.3K citations
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- Journal of Neuroscience
10 publications · 1.2K citations
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- Biochemical and Biophysical Research Communications
BBRC · 10 publications · 254 citations
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- Cell Death and Disease
9 publications · 616 citations
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- Proceedings of the National Academy of Sciences
PNAS · 9 publications · 1.8K citations
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