Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

Hyungjin Kim, Ho-Chou Tu, Decheng Ren, +5

Molecular Cell

MitophagySignal TransductionMitochondrial FunctionApoptosisAutophagy +7

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

Decheng Ren, Ho-Chou Tu, Hyungjin Kim, +7

Science

An interconnected hierarchical model of cell death regulation by the BCL-2 family

Hui‐Chen Chen, Masayuki Kanai, Akane Inoue‐Yamauchi, +12

Nature Cell Biology

Interconnected Hierarchical ModelSignal TransductionCell RegulationApoptosisImmunology +10

Oxidative stress-induced apoptosis in granulosa cells involves JNK, p53 and Puma

Hongyan Yang, Yan Xie, Dongyu Yang, +1

Oncotarget

Lipid PeroxidationApoptosisImmunologyCell DeathOxidative Stress-induced Apoptosis +18

Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice

Decheng Ren, Minghua Li, Chaojun Duan, +1

Cell Metabolism

Animal PhysiologyEnergy HomeostasisNeuropeptidesLeptin SensitivityMolecular Physiology +11

Neuronal SH2B1 is essential for controlling energy and glucose homeostasis

Decheng Ren, Yingjiang Zhou, David L. Morris, +3

Journal of Clinical Investigation

Effect of salvianolic acids from Radix Salviae miltiorrhizae on regional cerebral blood flow and platelet aggregation in rats

Minke Tang, Decheng Ren, Juntian Zhang, +1

Phytomedicine

Salvianolic AcidsCerebral Vascular RegulationOxysterolMedicinePlatelet Aggregation +11

The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage

Ho-Chou Tu, Decheng Ren, Gary X. Wang, +6

Proceedings of the National Academy of Sciences

NF-κB–inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action

Liang Sheng, Yingjiang Zhou, Zheng Chen, +6

Nature Medicine

ImmunologyInsulin SignalingObesityMetabolic SyndromeInflammation +15

SH2B Regulation of Growth, Metabolism, and Longevity in Both Insects and Mammals

Wei Song, Decheng Ren, Wenjun Li, +7

Cell Metabolism

BiologyEnergy MetabolismMammalian PhysiologyPhysiologyEntomology +4