Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice

Positional cloning of the mouse obese gene and its human homologue

Yiying Zhang, Ricardo Proenca, Margherita Maffei et al. · Nature · 1994 · 13.3K citations

Obesity, Metabolic Syndrome, Knockout Mouse +10

Identification and expression cloning of a leptin receptor, OB-R

Louis A. Tartaglia, Marlene Dembski, Xun Weng et al. · Cell · 1995 · 3.5K citations · Full text

Signal Transduction, Molecular Physiology, Hypothalamic Peptide +7

Congenital leptin deficiency is associated with severe early-onset obesity in humans

I. Sadaf Farooqi, Jonathan P. Whitehead, Maria A. Soos et al. · Nature · 1997 · 2.9K citations · Full text

Obesity, Metabolic Syndrome, Nutrition +10

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

Karine Clément, Christian Vaisse, Najiba Lahlou et al. · Nature · 1998 · 2.4K citations

Obesity, Metabolic Syndrome, Endocrine Mechanism +10

Abnormal splicing of the leptin receptor in diabetic mice

Gwo‐Hwa Lee, R Proenca, Jason Montez et al. · Nature · 1996 · 2.3K citations

Diabetes, Immunology, Hypothalamic Peptide +5