Concepedia

Origin Firing

Origin firing is a regulatory event in the cell cycle that refers to the initiation of DNA replication at specific genomic loci known as replication origins, where the assembly and activation of the replication machinery lead to the unwinding of DNA and the establishment of bidirectional replication forks.

131

Publications

10.6K

Citations

578

Authors

228

Institutions

Publications per year

2017–2026

37

Variants

Origin Activation

Parents

Publications

131

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

Eva Petermann, Manuel Luís Orta, Natalia Issaeva et al. · Molecular Cell · 2010 · 832 citations · Full text

, , +15

Regulated eukaryotic DNA replication origin firing with purified proteins

Joseph T.P. Yeeles, Tom Deegan, Agnieszka Janska et al. · Nature · 2015 · 530 citations · Full text

, , +12

Chk1 promotes replication fork progression by controlling replication initiation

Eva Petermann, Mick Woodcock, Thomas Helleday · Proceedings of the National Academy of Sciences · 2010 · 304 citations · Full text

, , +17

Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast

Davide Mantiero, Amanda E. Mackenzie, Anne D. Donaldson et al. · The EMBO Journal · 2011 · 303 citations · Full text

, , +13

Activation of S-phase-promoting CDKs in late G1 defines a "point of no return" after which Cdc6 synthesis cannot promote DNA replication in yeast.

Simonetta Piatti, Thomas Böhm, Julie H. Cocker et al. · Genes & Development · 1996 · 290 citations · Full text

, , +17

1–5 of 131

Authors

578

  1. OH
    Olivier Hyrien

    Centre National de la Recherche Scientifique, France

    4 publications · 276 citations

    5

    h-index

  2. JL
    Joyce L. Hamlin

    University of Virginia, United States

    4 publications · 283 citations

    4

    h-index

  3. JB
    John Bechhoefer

    Simon Fraser University, Canada

    4 publications · 311 citations

    4

    h-index

  4. MK
    M. K. Raghuraman

    University of Washington, United States

    4 publications · 364 citations

    4

    h-index

  5. AB
    Aaron Bensimon

    Institut Pasteur, France

    4 publications · 446 citations

    4

    h-index

1–5 of 578

Institutions

228

  1. Centre National de la Recherche Scientifique

    Paris, France

    12 h-index

    50 publications

    1.7K citations

  2. University of Oxford

    Oxford, United Kingdom

    6 h-index

    12 publications

    4.3K citations

  3. University of Massachusetts Chan Medical School

    Worcester, United States

    6 h-index

    11 publications

    997 citations

  4. Commissariat à l'Énergie Atomique et aux Énergies Alternatives

    Paris, France

    5 h-index

    7 publications

    261 citations

  5. University of Washington

    Seattle, United States

    5 h-index

    11 publications

    690 citations

  6. Inserm

    Paris, France

    5 h-index

    15 publications

    495 citations

  7. University of Southern California

    Los Angeles, United States

    4 h-index

    20 publications

    1.7K citations

  8. University of Cambridge

    Cambridge, United Kingdom

    4 h-index

    8 publications

    319 citations

1–8 of 228

Venues

  1. Nucleic Acids Research

    11 publications · 579 citations

    11

    h-index

  2. Molecular and Cellular Biology

    MCB · 9 publications · 590 citations

    9

    h-index

  3. Genome Research

    GR · 7 publications · 433 citations

    7

    h-index

  4. Cell Reports

    7 publications · 677 citations

    7

    h-index

  5. Cell Cycle

    6 publications · 276 citations

    6

    h-index

1–5