Concepedia

On-target Efficiency

On-Target Efficiency is a quantitative metric in CRISPR-Cas systems that measures the proportion of intended genomic edits successfully achieved at a specified target locus relative to all editing events, distinguishing it from off-target effects and overall editing efficiency by specifically capturing the accuracy and effectiveness of desired modifications.

117

Publications

16.6K

Citations

822

Authors

320

Institutions

Publications per year

2017–2026

86

Parents

Publications

117

Rationally engineered Cas9 nucleases with improved specificity

Ian M. Slaymaker, Linyi Gao, Bernd Zetsche et al. · Science · 2015 · 2.5K citations

, , +15

GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases

Shengdar Q. Tsai, Zongli Zheng, Nathalie T. Nguyen et al. · Nature Biotechnology · 2014 · 2.3K citations · Full text

, , +14

Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells

Robin M. Meyers, Jordan Bryan, James M. McFarland et al. · Nature Genetics · 2017 · 2.2K citations · Full text

, , +15

Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR

Maximilian Haeussler, Kai Schönig, Hélène Eckert et al. · Genome biology · 2016 · 1.9K citations · Full text

, , +14

Directed evolution of CRISPR-Cas9 to increase its specificity

Jungjoon K. Lee, Seokjoong Kim, Jin‐Soo Kim · Nature Communications · 2018 · 529 citations · Full text

, , +14

1–5 of 117

Authors

822

  1. JG
    John G. Doench

    Broad Institute, United States

    4 publications · 606 citations

    4

    h-index

  2. JG
    Jan Gorodkin

    University of Copenhagen, Denmark

    4 publications · 520 citations

    4

    h-index

  3. JK
    Jungjoon K. Lee

    ToolGen (South Korea), South Korea

    4 publications · 623 citations

    4

    h-index

  4. CA
    Christian Anthon

    University of Copenhagen, Denmark

    3 publications · 423 citations

    3

    h-index

  5. GI
    Giulia I. Corsi

    University of Copenhagen, Denmark

    3 publications · 344 citations

    3

    h-index

1–5 of 822

Institutions

320

  1. Harvard University

    Cambridge, United States

    12 h-index

    43 publications

    30.3K citations

  2. Broad Institute

    Cambridge, United States

    9 h-index

    81 publications

    88.2K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    6 h-index

    19 publications

    5.5K citations

  4. University of Chinese Academy of Sciences

    Beijing, China

    5 h-index

    14 publications

    1.2K citations

  5. Chinese Academy of Agricultural Sciences

    Beijing, China

    4 h-index

    24 publications

    1.1K citations

  6. Massachusetts General Hospital

    Boston, United States

    4 h-index

    27 publications

    29.4K citations

  7. ToolGen (South Korea)

    Seoul, South Korea

    4 h-index

    10 publications

    1.3K citations

  8. Dana-Farber Cancer Institute

    Boston, United States

    4 h-index

    9 publications

    11.1K citations

1–8 of 320

Venues

  1. Nature Communications

    14 publications · 1.6K citations

    14

    h-index

  2. Scientific Reports

    6 publications · 496 citations

    6

    h-index

  3. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 4 publications · 81 citations

    4

    h-index

  4. 4

    h-index

  5. Nature Biotechnology

    4 publications · 2.7K citations

    4

    h-index

1–5