Concepedia

Off-target Site Detection

Off-Target Site Detection is a computational method that identifies unintended interaction sites of targeted genome-editing or regulatory agents by distinguishing potential off-target effects from on-target activity through sequence homology, biochemical profiling, or empirical screening.

31

Publications

2.6K

Citations

194

Authors

94

Institutions

Publications per year

2017–2026

15

Parents

Publications

31

DeepCRISPR: optimized CRISPR guide RNA design by deep learning

Guohui Chuai, Hanhui Ma, Jifang Yan et al. · Genome biology · 2018 · 598 citations · Full text

, , +17

Identifying off-target effects and hidden phenotypes of drugs in human cells

Marnie L. MacDonald, Jane E. Lamerdin, Stephen Owens et al. · Nature Chemical Biology · 2006 · 297 citations

, , +16

A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture

Henriette O’Geen, Isabelle Henry, Mital S. Bhakta et al. · Nucleic Acids Research · 2015 · 221 citations · Full text

, , +13

dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference

Yuki Naito, Toshimichi Yamada, Teruhiko Matsumiya et al. · Nucleic Acids Research · 2005 · 187 citations · Full text

, , +14

A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens

Frederic Sigoillot, Susan K. Lyman, Jeremy F. Huckins et al. · Nature Methods · 2012 · 163 citations · Full text

, , +10

1–5 of 31

Authors

194

  1. TJ
    Thomas J. Cradick

    Georgia Institute of Technology, United States

    2 publications · 184 citations

    2

    h-index

  2. DJ
    David J. Segal

    University of California, Davis, United States

    2 publications · 231 citations

    2

    h-index

  3. JF
    Joshua F. Meckler

    University of California, Davis, United States

    2 publications · 231 citations

    2

    h-index

  4. MS
    Mital S. Bhakta

    University of California, Davis, United States

    2 publications · 231 citations

    2

    h-index

  5. HO
    Henriette O’Geen

    University of California, Davis, United States

    2 publications · 231 citations

    2

    h-index

1–5 of 194

Institutions

94

  1. Tel Aviv University

    Tel Aviv, Israel

    2 h-index

    2 publications

    56 citations

  2. Fudan University

    Shanghai, China

    2 h-index

    13 publications

    442 citations

  3. University of Massachusetts Chan Medical School

    Worcester, United States

    2 h-index

    12 publications

    1.2K citations

  4. Harvard University

    Cambridge, United States

    2 h-index

    9 publications

    1.3K citations

  5. University of California, Davis

    Davis, United States

    2 h-index

    10 publications

    1.2K citations

  6. Xiangtan University

    Xiangtan, China

    1 h-index

    1 publications

    28 citations

  7. Bar-Ilan University

    Ramat Gan, Israel

    1 h-index

    6 publications

    144 citations

  8. University of Iowa

    Iowa City, United States

    1 h-index

    2 publications

    100 citations

1–8 of 94

Venues

  1. Nature Communications

    6 publications · 284 citations

    5

    h-index

  2. Nucleic Acids Research

    4 publications · 565 citations

    4

    h-index

  3. PLoS Computational Biology

    2 publications · 111 citations

    2

    h-index

  4. Nature Methods

    2 publications · 239 citations

    2

    h-index

  5. Bioinformatics

    2 publications · 253 citations

    2

    h-index

1–5