David J. Segal

Endorphins: Profound Behavioral Effects in Rats Suggest New Etiological Factors in Mental Illness

Floyd E. Bloom, David J. Segal, Nicholas Ling et al. · Science · 1976 · 812 citations

Medicine, Neuroscience, Pharmacology +17

Stimulation of Homologous Recombination through Targeted Cleavage by Chimeric Nucleases

Marina Bibikova, Dana Carroll, David J. Segal et al. · Molecular and Cellular Biology · 2001 · 611 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +17

Toward controlling gene expression at will: Specific regulation of the <i>erbB</i> - <i>2</i> / <i>HER</i> - <i>2</i> promoter by using polydactyl zinc finger proteins constructed from modular building blocks

Roger R. Beerli, David J. Segal, Birgit Dreier et al. · Proceedings of the National Academy of Sciences · 1998 · 538 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases

Michal Szczepek, Vincent Brondani, Janine Büchel et al. · Nature Biotechnology · 2007 · 501 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences

David J. Segal, Birgit Dreier, Roger R. Beerli et al. · Proceedings of the National Academy of Sciences · 1999 · 423 citations

Life Sciences, Biology, Molecular Biology +17