Thomas J. Cradick

DNA targeting specificity of RNA-guided Cas9 nucleases

Patrick D. Hsu, David A. Scott, Joshua A. Weinstein et al. · Nature Biotechnology · 2013 · 4.9K citations · Full text

Life Sciences, Genetics, Molecular Biology +10

CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences

Yongjun Lin, Thomas J. Cradick, Matthew T. Brown et al. · Nucleic Acids Research · 2014 · 646 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

Thomas J. Cradick, Eli J. Fine, Christopher J. Antico et al. · Nucleic Acids Research · 2013 · 604 citations · Full text

Life Sciences, Genetics, Molecular Biology +15

COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites

Thomas J. Cradick, Peng Qiu, Ciaran M. Lee et al. · Molecular Therapy — Nucleic Acids · 2014 · 427 citations · Full text

Life Sciences, Bioinformatics, Genetics +13

Seamless modification of wild-type induced pluripotent stem cells to the natural CCR5Δ32 mutation confers resistance to HIV infection

Lin Ye, Jiaming Wang, Ashley I. Beyer et al. · Proceedings of the National Academy of Sciences · 2014 · 318 citations · Full text

Life Sciences, Genetics, Molecular Biology +16