Concepedia

Mitochondrial Mutation Correction

Mitochondrial Mutation Correction is a targeted molecular intervention that belongs to the class of genome editing techniques and specifically distinguishes itself by enabling the precise repair or replacement of pathogenic mutations within the mitochondrial DNA without altering the nuclear genome.

38

Publications

3.6K

Citations

259

Authors

90

Institutions

Publications per year

2017–2026

23

Parents

Publications

38

Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs

Sandra R. Bacman, Siôn L. Williams, Milena Pinto et al. · Nature Medicine · 2013 · 436 citations

, , +16

Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo

Payam A. Gammage, Carlo Viscomi, Marie‐Lune Simard et al. · Nature Medicine · 2018 · 305 citations

, , +16

Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing

Pradeep Reddy, Alejandro Ocampo, Keiichiro Suzuki et al. · Cell · 2015 · 286 citations · Full text

, , +11

MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation

Sandra R. Bacman, Johanna H.K. Kauppila, Cláudia V. Pereira et al. · Nature Medicine · 2018 · 283 citations

, , +14

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction

Laurie H. Sanders, Josée Laganière, Oliver Cooper et al. · Neurobiology of Disease · 2013 · 277 citations · Full text

, , +17

1–5 of 38

Authors

259

  1. CT
    Carlos T. Moraes

    University of Miami, United States

    6 publications · 1.2K citations

    6

    h-index

  2. SR
    Sandra R. Bacman

    University of Miami, United States

    6 publications · 1.2K citations

    6

    h-index

  3. JB
    James B. Stewart

    Max Planck Institute for Biology of Ageing, Germany

    3 publications · 679 citations

    3

    h-index

  4. SL
    Siôn L. Williams

    University of Miami, United States

    3 publications · 1K citations

    3

    h-index

  5. CV
    Cláudia V. Pereira

    University of Coimbra, Portugal

    3 publications · 456 citations

    3

    h-index

1–5 of 259

Institutions

90

  1. University of Miami

    Coral Gables, United States

    6 h-index

    28 publications

    5.8K citations

  2. Newcastle University

    Newcastle upon Tyne, United Kingdom

    3 h-index

    6 publications

    214 citations

  3. Harvard University

    Cambridge, United States

    3 h-index

    3 publications

    329 citations

  4. Sangamo BioSciences (United States)

    Richmond, United States

    2 h-index

    8 publications

    2.3K citations

  5. Institute for Basic Science

    Daejeon, South Korea

    2 h-index

    10 publications

    1.4K citations

  6. Kyoto University

    Kyoto, Japan

    2 h-index

    6 publications

    143 citations

  7. Nanjing Medical University

    Nanjing, China

    2 h-index

    21 publications

    1.7K citations

  8. Nanjing Maternity and Child Health Care Hospital

    Nanjing, China

    2 h-index

    3 publications

    238 citations

1–8 of 90

Venues

  1. Nature Medicine

    3 publications · 1K citations

    3

    h-index

  2. Cell

    2 publications · 307 citations

    2

    h-index

  3. Nature Communications

    2 publications · 248 citations

    2

    h-index

  4. Molecular Therapy — Nucleic Acids

    2 publications · 156 citations

    2

    h-index

  5. Science

    2 publications · 45 citations

    2

    h-index

1–5