Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

Frank Soldner, Dirk Hockemeyer, Caroline Beard, +9

Cell

Induced Pluripotent Stem CellMedicineAdult Stem CellImmunologyViral Reprogramming Factors +6

Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson’s Disease

Oliver Cooper, Hyemyung Seo, Shaida A. Andrabi, +36

Science Translational Medicine

Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats

Gunnar Hargus, Oliver Cooper, Michela Deleidi, +10

Proceedings of the National Academy of Sciences

Adult Stem CellSocial SciencesRegenerative MedicineNeuroregenerationParkinsonian Rats +18

Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease

Ivar Mendez, Rosario Sánchez‐Pernaute, Oliver Cooper, +5

Brain

Neurobiology Of DiseaseSubstantia NigraMedicineTransplanted Dopamine NeuronsImmunology +13

Successful Function of Autologous iPSC-Derived Dopamine Neurons following Transplantation in a Non-Human Primate Model of Parkinson’s Disease

Penelope J. Hallett, Michela Deleidi, Arnar Astradsson, +10

Cell stem cell

Neurodegenerative DiseasesNeurobiology Of DiseaseNon-human Primate ModelParkinson ’Neuropharmacology +8

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction

Laurie H. Sanders, Josée Laganière, Oliver Cooper, +13

Neurobiology of Disease

MitophagyNeurodegenerative DiseasesMolecular NeuroscienceMitochondrial FunctionGenetics +9

Improved Cell Therapy Protocols for Parkinson's Disease Based on Differentiation Efficiency and Safety of hESC-, hiPSC-, and Non-Human Primate iPSC-Derived Dopaminergic Neurons

Maria Sundberg, Helle Bogetofte, Tristan Lawson, +9

Stem Cells

Cell TherapyCellular TherapiesNeuroregenerationNeurologyDifferentiation Efficiency +16

Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid

Oliver Cooper, Gunnar Hargus, Michela Deleidi, +8

Molecular and Cellular Neuroscience

Neurodegenerative DiseasesHuman EsDevelopmental BiologyNeuroanatomyRetinoic Acid +8

Selective COX-2 inhibition prevents progressive dopamine neuron degeneration in a rat model of Parkinson's disease.

Rosario Sánchez‐Pernaute, Andrew Ferree, Oliver Cooper, +3

Journal of Neuroinflammation

Intrastriatal Transforming Growth Factor α Delivery to a Model of Parkinson's Disease Induces Proliferation and Migration of Endogenous Adult Neural Progenitor Cells without Differentiation into Dopaminergic Neurons

Oliver Cooper, Ole Isacson

Journal of Neuroscience