Sandra R. Bacman

Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs

Sandra R. Bacman, Siôn L. Williams, Milena Pinto et al. · Nature Medicine · 2013 · 429 citations · Full text

Mitophagy, Mitochondrial Function, Medicine +11

Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing

Pradeep Reddy, Alejandro Ocampo, Keiichiro Suzuki et al. · Cell · 2015 · 283 citations · Full text

Mitochondrial Function, Natural Sciences, Genetics +11

MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation

Sandra R. Bacman, Johanna H.K. Kauppila, Cláudia V. Pereira et al. · Nature Medicine · 2018 · 276 citations

Biology, Genome Instability, Mitochondrial Function +9

Cytochrome<i>c</i>Association with the Inner Mitochondrial Membrane Is Impaired in the CNS of G93A-SOD1 Mice

Ilias G. Kirkinezos, Sandra R. Bacman, Dayami Hernandez et al. · Journal of Neuroscience · 2005 · 197 citations · Full text

MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases

Masami Hashimoto, Sandra R. Bacman, Susana Peralta et al. · Molecular Therapy · 2015 · 189 citations · Full text