Concepedia

Lipophilicity Modification

Lipophilicity Modification is a solubility enhancement strategy that alters the lipid solubility of a bioactive compound through structural or chemical changes to improve its membrane permeability and overall bioavailability.

238

Publications

10.2K

Citations

1.4K

Authors

400

Institutions

Publications per year

2017–2026

75

Parents

Publications

238

Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space

Alexander Alex, David S. Millan, Manuel Pérez et al. · MedChemComm · 2011 · 323 citations

, , +17

Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development

Jeffrey M. Axten, Stuart P. Romeril, Arthur Y. L. Shu et al. · ACS Medicinal Chemistry Letters · 2013 · 230 citations · Full text

, , +16

Lipophilized Epigallocatechin Gallate (EGCG) Derivatives as Novel Antioxidants

Ying Zhong, Fereidoon Shahidi · Journal of Agricultural and Food Chemistry · 2011 · 229 citations

, , +17

Organic-Inorganic Hybrid Zeolites Containing Organic Frameworks

Katsutoshi Yamamoto, Yasuyuki Sakata, Yuki Nohara et al. · Science · 2003 · 199 citations

, , +12

An Analysis of the Binding Efficiencies of Drugs and Their Leads in Successful Drug Discovery Programs

Emanuele Perola · Journal of Medicinal Chemistry · 2010 · 191 citations

, , +16

1–5 of 238

Authors

1.4K

  1. JS
    James S. Scott

    AstraZeneca (United Kingdom), United Kingdom

    5 publications · 283 citations

    5

    h-index

  2. BL
    Bruno Linclau

    University of Southampton, United Kingdom

    4 publications · 242 citations

    4

    h-index

  3. RK
    Ravindra K. Pandey

    Roswell Park Comprehensive Cancer Center, United States

    4 publications · 141 citations

    4

    h-index

  4. EC
    Elisabetta Chiarparin

    AstraZeneca (United Kingdom), United Kingdom

    3 publications · 210 citations

    3

    h-index

  5. AR
    Allan R. Oseroff

    Roswell Park Comprehensive Cancer Center, United States

    3 publications · 119 citations

    3

    h-index

1–5 of 1.4K

Institutions

400

  1. AstraZeneca (United Kingdom)

    Cambridge, United Kingdom

    9 h-index

    45 publications

    2.4K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    21 publications

    726 citations

  3. University of Bari Aldo Moro

    Bari, Italy

    5 h-index

    33 publications

    866 citations

  4. Universidade do Porto

    Porto, Portugal

    5 h-index

    27 publications

    1K citations

  5. South China University of Technology

    Guangzhou, China

    4 h-index

    13 publications

    335 citations

  6. University of Southampton

    Southampton, United Kingdom

    4 h-index

    19 publications

    1.1K citations

  7. Rede de Química e Tecnologia

    Porto, Portugal

    4 h-index

    20 publications

    803 citations

  8. Roswell Park Comprehensive Cancer Center

    Buffalo, United States

    4 h-index

    32 publications

    1.2K citations

1–8 of 400

Venues

  1. Journal of Medicinal Chemistry

    34 publications · 2K citations

    27

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    7 publications · 193 citations

    7

    h-index

  3. Journal of Agricultural and Food Chemistry

    6 publications · 520 citations

    6

    h-index

  4. International Journal of Pharmaceutics

    6 publications · 270 citations

    6

    h-index

  5. The Journal of Organic Chemistry

    JOC · 6 publications · 177 citations

    6

    h-index

1–5