Human Cell Base Editing is a genome engineering technique that enables precise, programmable alteration of single nucleotides in human cellular DNA without inducing double-strand breaks, distinguishing it from traditional gene editing methods by its reliance on modified CRISPR-associated proteins fused to base-modifying enzymes.
32
Publications
2.9K
Citations
319
Authors
122
Institutions
Publications per year
2017–2026
31
Parents
Publications
32
Isolation of single-base genome-edited human iPS cells without antibiotic selection
Yuichiro Miyaoka, Amanda H. Chan, Luke M. Judge et al. · Nature Methods · 2014 · 339 citations · Full text
Dual base editor catalyzes both cytosine and adenine base conversions in human cells
Xiaohui Zhang, Biyun Zhu, Liang Chen et al. · Nature Biotechnology · 2020 · 294 citations
Therapeutic base editing of human hematopoietic stem cells
Jing Zeng, Yuxuan Wu, Chunyan Ren et al. · Nature Medicine · 2020 · 280 citations · Full text
Genotoxic effects of base and prime editing in human hematopoietic stem cells
Martina Fiumara, Samuele Ferrari, Attya Omer et al. · Nature Biotechnology · 2023 · 216 citations · Full text
Correction of β-thalassemia mutant by base editor in human embryos
Puping Liang, Chenhui Ding, Hong‐Wei Sun et al. · Protein & Cell · 2017 · 214 citations · Full text
1–5 of 32
Authors
319
- JK
3
h-index
- FG
3
h-index
- XL
3
h-index
- TT
3
h-index
- DL
3
h-index
1–5 of 319
Institutions
122
Chinese Academy of Sciences
Beijing, China
9 h-index
30 publications
1.7K citations
Harvard University
Cambridge, United States
6 h-index
38 publications
5K citations
East China Normal University
Shanghai, China
5 h-index
37 publications
6.5K citations
University of Chinese Academy of Sciences
Beijing, China
4 h-index
6 publications
278 citations
Shanghai Jiao Tong University
Shanghai, China
4 h-index
10 publications
593 citations
Massachusetts General Hospital
Boston, United States
4 h-index
16 publications
2K citations
Center for Excellence in Molecular Cell Science
Shanghai, China
3 h-index
7 publications
290 citations
Broad Institute
Cambridge, United States
3 h-index
17 publications
3.9K citations
1–8 of 122
Venues
- Nature Communications
6 publications · 290 citations
6
h-index
- Nature Biotechnology
4 publications · 854 citations
4
h-index
- Molecular Therapy
3 publications · 229 citations
3
h-index
- Nucleic Acids Research
3 publications · 152 citations
3
h-index
- Nature
2 publications · 126 citations
2
h-index
1–5