Concepedia

Fragment Hit Validation

Fragment Hit Validation is a methodological process in drug discovery that confirms the binding of a low-molecular-weight fragment to a biological target with high confidence, distinguishing it from related screening validation approaches by its emphasis on detecting weak but specific interactions through biophysical and structural techniques.

20

Publications

996

Citations

156

Authors

53

Institutions

Publications per year

2017–2026

11

Parents

Publications

20

A three-stage biophysical screening cascade for fragment-based drug discovery

Ellene H. Mashalidis, P. Sledz, Steffen Lang et al. · Nature Protocols · 2013 · 135 citations

, , +14

Protein-observed 19F-NMR for fragment screening, affinity quantification and druggability assessment

Clifford T. Gee, Keith E. Arntson, Andrew K. Urick et al. · Nature Protocols · 2016 · 106 citations · Full text

, , +16

Fragment-Based Screening of the Bromodomain of ATAD2

Mary J. Harner, Brian A. Chauder, Jason Phan et al. · Journal of Medicinal Chemistry · 2014 · 82 citations · Full text

, , +14

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source

A. Douangamath, A.J. Powell, D. Fearon et al. · Journal of Visualized Experiments · 2021 · 78 citations · Full text

, , +17

Fragment Hits: What do They Look Like and How do They Bind?

Fabrizio Giordanetto, Chentian Jin, Lindsay Willmore et al. · Journal of Medicinal Chemistry · 2019 · 77 citations · Full text

, , +17

1–5 of 20

Authors

156

  1. HB
    Hannes Baukmann

    Max Planck Institute of Colloids and Interfaces, Germany

    2 publications · 81 citations

    2

    h-index

  2. CR
    Christoph Rademacher

    Max Planck Institute of Colloids and Interfaces, Germany

    2 publications · 81 citations

    2

    h-index

  3. RW
    Robert Wawrzinek

    The University of Queensland, Australia

    2 publications · 81 citations

    2

    h-index

  4. JA
    Jonas Aretz

    Max Planck Institute of Colloids and Interfaces, Germany

    2 publications · 81 citations

    2

    h-index

  5. AB
    Amy B. Heptinstall

    Newcastle University, United Kingdom

    1 publications · 17 citations

    1

    h-index

1–5 of 156

Institutions

53

  1. Nanyang Technological University

    Singapore, Singapore

    2 h-index

    2 publications

    93 citations

  2. Max Planck Institute of Colloids and Interfaces

    Potsdam, Germany

    2 h-index

    13 publications

    539 citations

  3. University of Cambridge

    Cambridge, United Kingdom

    2 h-index

    8 publications

    695 citations

  4. Freie Universität Berlin

    Berlin, Germany

    2 h-index

    12 publications

    486 citations

  5. Newcastle upon Tyne Hospital

    Newcastle upon Tyne, United Kingdom

    1 h-index

    15 publications

    255 citations

  6. GlaxoSmithKline (Ireland)

    Cork, Ireland

    1 h-index

    11 publications

    649 citations

  7. University of Strathclyde

    Glasgow, United Kingdom

    1 h-index

    3 publications

    177 citations

  8. Institute of Molecular and Cell Biology

    Singapore, Singapore

    1 h-index

    3 publications

    102 citations

1–8 of 53

Venues

  1. Journal of Medicinal Chemistry

    4 publications · 216 citations

    4

    h-index

  2. Angewandte Chemie International Edition

    3 publications · 145 citations

    3

    h-index

  3. ACS Medicinal Chemistry Letters

    2 publications · 83 citations

    2

    h-index

  4. Nature Protocols

    2 publications · 241 citations

    2

    h-index

  5. PLoS ONE

    2 publications · 55 citations

    2

    h-index

1–5