Concepedia

Enzyme Mutagenesis

Enzyme Mutagenesis is a molecular biology technique that involves the targeted alteration of specific amino acid residues within an enzyme's sequence to investigate or modulate its structural, catalytic, or regulatory properties.

485

Publications

22K

Citations

1.9K

Authors

592

Institutions

Publications per year

2017–2026

31

Parents

Publications

485

Iterative saturation mutagenesis (ISM) for rapid directed evolution of functional enzymes

Manfred T. Reetz, José Daniel Carballeira · Nature Protocols · 2007 · 866 citations

, , +15

Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide.

Kun Chen, Frances H. Arnold · Proceedings of the National Academy of Sciences · 1993 · 541 citations

, , +16

Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding

Greg Winter, Alan R. Fersht, Anthony J. Wilkinson et al. · Nature · 1982 · 356 citations

, , +17

Engineering an enzyme by site-directed mutagenesis to be resistant to chemical oxidation.

David A. Estell, Thomas P. Graycar, James A. Wells · Journal of Biological Chemistry · 1985 · 336 citations · Full text

, , +17

A general method of site-specific mutagenesis using a modification of the Thermus aquaticus polymerase chain reaction

Richard M. Nelson, George L. Long · Analytical Biochemistry · 1989 · 320 citations

, , +8

1–5 of 485

Authors

1.9K

  1. HR
    H. Ronald Kaback

    University of California, Los Angeles, United States

    6 publications · 260 citations

    6

    h-index

  2. TL
    Terence L. Kirley

    University of Cincinnati Medical Center, United States

    6 publications · 299 citations

    6

    h-index

  3. PC
    Paul C. Engel

    University of Sheffield, United Kingdom

    6 publications · 115 citations

    6

    h-index

  4. HJ
    Herbert J. Fromm

    Iowa State University, United States

    5 publications · 80 citations

    5

    h-index

  5. DB
    Didier Blanot

    Centre National de la Recherche Scientifique, France

    4 publications · 224 citations

    4

    h-index

1–5 of 1.9K

Institutions

592

  1. Centre National de la Recherche Scientifique

    Paris, France

    16 h-index

    58 publications

    2.3K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    10 h-index

    26 publications

    1.9K citations

  3. University of Sheffield

    Sheffield, United Kingdom

    9 h-index

    29 publications

    946 citations

  4. The University of Osaka

    Osaka, Japan

    8 h-index

    37 publications

    1.2K citations

  5. Uppsala University

    Uppsala, Sweden

    7 h-index

    17 publications

    1.2K citations

  6. Michigan State University

    East Lansing, United States

    6 h-index

    19 publications

    746 citations

  7. University of Cincinnati

    Cincinnati, United States

    6 h-index

    15 publications

    769 citations

  8. Purdue University West Lafayette

    West Lafayette, United States

    6 h-index

    21 publications

    1.7K citations

1–8 of 592

Venues

  1. Journal of Biological Chemistry

    JBC · 81 publications · 4.2K citations

    41

    h-index

  2. Biochemistry

    60 publications · 3.1K citations

    35

    h-index

  3. Biochemical Journal

    BJ · 22 publications · 1K citations

    18

    h-index

  4. Protein Engineering Design and Selection

    PEDS · 16 publications · 464 citations

    13

    h-index

  5. Biochemical and Biophysical Research Communications

    BBRC · 15 publications · 429 citations

    13

    h-index

1–5