Apoptosome Assembly is the molecular process in which cytochrome c, released from mitochondria, binds to Apaf-1 to induce oligomerization into a heptameric platform that recruits and activates procaspase-9, thereby initiating the intrinsic pathway of apoptosis.
155
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19.7K
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752
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275
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Publications per year
2017–2026
18
Publications
155
Three-Dimensional Structure of the Apoptosome
Devrim Acehan, Xuejun Jiang, David Morgan et al. · Molecular Cell · 2002 · 895 citations · Full text
Negative regulation of the Apaf-1 apoptosome by Hsp70
Ayman Saleh, Srinivasa M. Srinivasula, Levent Balkir et al. · Nature Cell Biology · 2000 · 820 citations
1–5 of 155
Authors
752
- CW
10
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10
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8
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7
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- SB
7
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1–5 of 752
Institutions
275
Boston University
Boston, United States
10 h-index
27 publications
4.8K citations
Howard Hughes Medical Institute
Chevy Chase, United States
9 h-index
21 publications
13.2K citations
University of Leicester
Leicester, United Kingdom
9 h-index
43 publications
10.1K citations
The University of Texas Southwestern Medical Center
Dallas, United States
8 h-index
21 publications
12.8K citations
Tsinghua University
Beijing, China
7 h-index
47 publications
5.4K citations
MRC Toxicology Unit
Cambridge, United Kingdom
6 h-index
21 publications
5.1K citations
Center for Life Sciences
Beijing, China
6 h-index
28 publications
4.5K citations
Medical Research Council
London, United Kingdom
6 h-index
23 publications
3.7K citations
1–8 of 275
Venues
- Journal of Biological Chemistry
JBC · 23 publications · 5.2K citations
23
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- Proceedings of the National Academy of Sciences
PNAS · 7 publications · 867 citations
7
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- Structure
6 publications · 489 citations
6
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- Biochemistry
5 publications · 221 citations
5
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- Cell Death and Differentiation
CDD · 5 publications · 264 citations
5
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