Concepedia

Datp-dependent Assembly

DATP-Dependent Assembly is a biochemical mechanism in the context of apoptosome formation wherein the oligomerization of Apaf-1 and recruitment of procaspase-9 strictly require deoxyadenosine triphosphate (dATP) as a nucleotide cofactor to initiate the intrinsic pathway of apoptosis.

4

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7.6K

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25

Authors

10

Institutions

Publications per year

2017–2026

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Publications

4

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

Peng Li, Deepak Nijhawan, I. Imawati Budihardjo et al. · Cell · 1997 · 7.3K citations · Full text

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Apaf-1 Oligomerizes into Biologically Active ∼700-kDa and Inactive ∼1.4-MDa Apoptosome Complexes

Kelvin Cain, Shawn B. Bratton, Claudia Langlais et al. · Journal of Biological Chemistry · 2000 · 315 citations · Full text

, , +16

An endogenous dAMP ligand in <i>Bacillus subtilis</i> class Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP

Mackenzie J. Parker, Ailiena O. Maggiolo, William C. Thomas et al. · Proceedings of the National Academy of Sciences · 2018 · 26 citations · Full text

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Dynamics of the dATP pool in cultured mammalian cells

Vera Bianchi, E Pontis, Peter Reichard · Experimental Cell Research · 1992 · 13 citations

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1–4 of 4

Authors

25

  1. SM
    Srinivasa M. Srinivasula

    Thomas Jefferson University, United States

    1 publications · 7.3K citations

    1

    h-index

  2. VB
    Vera Bianchi

    University of Padua, Italy

    1 publications · 13 citations

    1

    h-index

  3. EP
    E Pontis

    Karolinska Institutet, Sweden

    1 publications · 13 citations

    1

    h-index

  4. GW
    Gail Walker

    Sylvester Comprehensive Cancer Center, United States

    1 publications · 315 citations

    1

    h-index

  5. CL
    Claudia Langlais

    MRC Toxicology Unit, United Kingdom

    1 publications · 315 citations

    1

    h-index

1–5 of 25

Institutions

10

  1. Thomas Jefferson University

    Philadelphia, United States

    1 h-index

    3 publications

    21.8K citations

  2. Pennsylvania State University

    State College, United States

    1 h-index

    2 publications

    52 citations

  3. University of Leicester

    Leicester, United Kingdom

    1 h-index

    7 publications

    2.2K citations

  4. Karolinska Institutet

    Stockholm, Sweden

    1 h-index

    3 publications

    39 citations

  5. MRC Toxicology Unit

    Cambridge, United Kingdom

    1 h-index

    1 publications

    315 citations

  6. The University of Texas Southwestern Medical Center

    Dallas, United States

    1 h-index

    3 publications

    21.8K citations

  7. Princeton University

    Princeton, United States

    1 h-index

    3 publications

    78 citations

  8. Genesis Foundation

    New York, United States

    1 h-index

    1 publications

    315 citations

1–8 of 10

Venues

  1. Experimental Cell Research

    ECR · 1 publications · 13 citations

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  2. Journal of Biological Chemistry

    JBC · 1 publications · 315 citations

    1

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  3. Cell

    1 publications · 7.3K citations

    1

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  4. Proceedings of the National Academy of Sciences

    PNAS · 1 publications · 26 citations

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