AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

Patrick P. Zarrinkar, Ruwanthi N. Gunawardane, Merryl Cramer, +13

Blood

Identification of <i>N</i>-(5-<i>tert</i>-Butyl-isoxazol-3-yl)-<i>N</i>′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-<i>b</i>][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Selective, and Efficacious FMS-Like Tyrosine Kinase-3 (FLT3) Inhibitor

Qi Chao, Kelly G. Sprankle, Robert M. Grotzfeld, +10

Journal of Medicinal Chemistry

Drug TargetAml PatientsPharmacotherapyChemical BiologyPharmaceutical Chemistry +18

Substituted Isoquinolines and Quinazolines as Potential Antiinflammatory Agents. Synthesis and Biological Evaluation of Inhibitors of Tumor Necrosis Factor α

Qi Chao, Lynn Deng, Hsiencheng Shih, +4

Journal of Medicinal Chemistry

Identification of 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Hydrochloride (CEP-32496), a Highly Potent and Orally Efficacious Inhibitor of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) V600E

Martin W. Rowbottom, Raffaella Faraoni, Qi Chao, +29

Journal of Medicinal Chemistry

Orally Efficacious InhibitorChemoprevention StrategyImmunologySeveral BrafAntiviral Drug +17

Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors

James J. Crawford, Wendy Lee, Ignacio Aliagas, +16

Journal of Medicinal Chemistry

Medicinal ChemistryPharmaceutical ChemistryDrug TargetBiochemistryMedicine +10

Arylcarboxyamino-substituted diaryl ureas as potent and selective FLT3 inhibitors

Hitesh Patel, Robert M. Grotzfeld, Andiliy Lai, +12

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryMedicinePharmacological AgentPharmacotherapy +5

Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability

Xiaojing Wang, Aleksandr Kolesnikov, Suzanne Tay, +17

Journal of Medicinal Chemistry

Pharmaceutical ScienceBioorganic ChemistryPim KinasesPharmacotherapyLead Series +16

Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors

Huiyong Hu, Xiaojing Wang, Grace Ka Yan Chan, +13

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryPotent Pan-pim InhibitorsMedicinePharmacotherapy +4

Concise and stereospecific synthesis of novel bicyclic dideoxynucleosides as potential antiviral agents

Qi Chao, Jianzhong Zhang, Lea Pickering, +2

Tetrahedron

Stereospecific SynthesisBiochemistryMedicineAntiviral Drug DevelopmentNovel Bicyclic Dideoxynucleosides +6

Synthesis of bicarbocyclic dideoxynucleosides as potential antiviral agents

Qi Chao, Vasu Nair

Tetrahedron

Bicarbocyclic DideoxynucleosidesMedicineAntiviral Drug DevelopmentAntiviral DrugPharmacology +2