Qi Chao

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

Patrick P. Zarrinkar, Ruwanthi N. Gunawardane, Merryl Cramer et al. · Blood · 2009 · 644 citations · Full text

Medicine, Medicinal Chemistry, Oncology +14

Identification of <i>N</i>-(5-<i>tert</i>-Butyl-isoxazol-3-yl)-<i>N</i>′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-<i>b</i>][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Selective, and Efficacious FMS-Like Tyrosine Kinase-3 (FLT3) Inhibitor

Qi Chao, Kelly G. Sprankle, Robert M. Grotzfeld et al. · Journal of Medicinal Chemistry · 2009 · 195 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Substituted Isoquinolines and Quinazolines as Potential Antiinflammatory Agents. Synthesis and Biological Evaluation of Inhibitors of Tumor Necrosis Factor α

Qi Chao, Lynn Deng, Hsiencheng Shih et al. · Journal of Medicinal Chemistry · 1999 · 162 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Identification of 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Hydrochloride (CEP-32496), a Highly Potent and Orally Efficacious Inhibitor of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) V600E

Martin W. Rowbottom, Raffaella Faraoni, Qi Chao et al. · Journal of Medicinal Chemistry · 2011 · 58 citations · Full text

Medicine, Oncology, Pharmacology +14

Structure-Guided Design of Group I Selective p21-Activated Kinase Inhibitors

James J. Crawford, Wendy Lee, Ignacio Aliagas et al. · Journal of Medicinal Chemistry · 2015 · 40 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16