Kelly G. Sprankle

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

Patrick P. Zarrinkar, Ruwanthi N. Gunawardane, Merryl Cramer et al. · Blood · 2009 · 630 citations · Full text

Identification of <i>N</i>-(5-<i>tert</i>-Butyl-isoxazol-3-yl)-<i>N</i>′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-<i>b</i>][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Selective, and Efficacious FMS-Like Tyrosine Kinase-3 (FLT3) Inhibitor

Qi Chao, Kelly G. Sprankle, Robert M. Grotzfeld et al. · Journal of Medicinal Chemistry · 2009 · 189 citations · Full text

Drug Target, Aml Patients, Pharmacotherapy +20

Structure-Based Design, Synthesis, and Antimicrobial Activity of Indazole-Derived SAH/MTA Nucleosidase Inhibitors

Xiaoming Li, Sam Chu, Victoria A. Feher et al. · Journal of Medicinal Chemistry · 2003 · 160 citations · Full text

Core Scaffold, Combinatorial Chemistry, Medicinal Chemistry +14

Single and Bis Peptide Nucleic Acids as Triplexing Agents: Binding and Stoichiometry

Michael Griffith, Lisa M. Risen, Michael J. Greig et al. · Journal of the American Chemical Society · 1995 · 145 citations

Peptide Engineering, Biological Mass Spectrometry, Molecular Biology +18

Deconvolution of Combinatorial Libraries for Drug Discovery:  Experimental Comparison of Pooling Strategies

Laura Wilson-Lingardo, Peter W. Davis, David J. Ecker et al. · Journal of Medicinal Chemistry · 1996 · 74 citations

Combinatorial Chemistry, Bioorganic Chemistry, Combinatorial Libraries +21