Ruwanthi N. Gunawardane

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

Patrick P. Zarrinkar, Ruwanthi N. Gunawardane, Merryl Cramer et al. · Blood · 2009 · 630 citations · Full text

Systematic gene tagging using CRISPR/Cas9 in human stem cells to illuminate cell organization

Brock Roberts, Amanda Haupt, Andrew M. Tucker et al. · Molecular Biology of the Cell · 2017 · 283 citations

Systematic Gene, Genetics, Fluorescent Tags +16

Identification of <i>N</i>-(5-<i>tert</i>-Butyl-isoxazol-3-yl)-<i>N</i>′-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-<i>b</i>][1,3]benzothiazol-2-yl]phenyl}urea Dihydrochloride (AC220), a Uniquely Potent, Selective, and Efficacious FMS-Like Tyrosine Kinase-3 (FLT3) Inhibitor

Qi Chao, Kelly G. Sprankle, Robert M. Grotzfeld et al. · Journal of Medicinal Chemistry · 2009 · 189 citations · Full text

Drug Target, Aml Patients, Pharmacotherapy +20

MYC regulation of a “poor-prognosis” metastatic cancer cell state

Anita Wolfer, Ben S. Wittner, Daniel Irimia et al. · Proceedings of the National Academy of Sciences · 2010 · 173 citations · Full text

Integrated intracellular organization and its variations in human iPS cells

Matheus P. Viana, Jianxu Chen, Theo Knijnenburg et al. · Nature · 2023 · 128 citations · Full text