Martin W. Rowbottom

Discovery of Sodium <i>R</i>-(+)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2<i>H</i>-pyrimidin-1-yl]-1-phenylethylamino}butyrate (Elagolix), a Potent and Orally Available Nonpeptide Antagonist of the Human Gonadotropin-Releasing Hormone Receptor

Chen Chen, Dongpei Wu, Zhiqiang Guo et al. · Journal of Medicinal Chemistry · 2008 · 117 citations · Full text

Novel Uracil Phenylethylamines, Gynecology, Pharmacotherapy +16

Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX

John H. Hutchinson, Martin W. Rowbottom, David Lonergan et al. · ACS Medicinal Chemistry Letters · 2017 · 82 citations · Full text

Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)

Martin W. Rowbottom, Gretchen Bain, Imelda Calderon et al. · Journal of Medicinal Chemistry · 2017 · 65 citations · Full text

Initial Hit 2, Pharmacotherapy, Chemical Biology +21

Potent imidazole and triazole CB 1 receptor antagonists related to SR141716

Brian Dyck, Val S. Goodfellow, Teresa A. Phillips et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 65 citations · Full text

Molecular Pharmacology, Biochemistry, Functional Selectivity +10

Identification of 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Hydrochloride (CEP-32496), a Highly Potent and Orally Efficacious Inhibitor of V-RAF Murine Sarcoma Viral Oncogene Homologue B1 (BRAF) V600E

Martin W. Rowbottom, Raffaella Faraoni, Qi Chao et al. · Journal of Medicinal Chemistry · 2011 · 58 citations · Full text

Orally Efficacious Inhibitor, Chemoprevention Strategy, Immunology +19