Imelda Calderon

Discovery of the First Potent and Orally Efficacious Agonist of the Orphan G-Protein Coupled Receptor 119

Graeme Semple, Beatriz Fioravanti, Imelda Calderon et al. · Journal of Medicinal Chemistry · 2008 · 141 citations · Full text

Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor

Daniel J. Buzard, Sun Hee Kim, Luis Lopez et al. · ACS Medicinal Chemistry Letters · 2014 · 70 citations · Full text

Immunology, Potent Functional Antagonist, Inflammation +20

Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control

Graeme Semple, Albert Ren, Beatriz Fioravanti et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 66 citations · Full text

Signal Transduction, Molecular Physiology, Biochemistry +12

Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding

Adam J. Stein, Gretchen Bain, Pat Prodanovich et al. · Molecular Pharmacology · 2015 · 65 citations

Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)

Martin W. Rowbottom, Gretchen Bain, Imelda Calderon et al. · Journal of Medicinal Chemistry · 2017 · 65 citations · Full text

Initial Hit 2, Pharmacotherapy, Chemical Biology +21