Alexander Khvat

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Sungsoon Fang, Jae Myoung Suh, Shannon M. Reilly et al. · Nature Medicine · 2015 · 711 citations · Full text

Medicine, Pharmacology, Physiology +15

Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1<i>H</i>-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy

Gianluca Papeo, Helena Posteri, Daniela Borghi et al. · Journal of Medicinal Chemistry · 2015 · 143 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +13

Synthesis and biological evaluation of novel γ-carboline analogues of Dimebon as potent 5-HT6 receptor antagonists

Alexandre V. Ivachtchenko, E.B. Frolov, Oleg D. Mitkin et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 51 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

A new insight into the Pfitzinger reaction. A facile synthesis of 6-sulfamoylquinoline-4-carboxylic acids

Alexandre V. Ivachtchenko, Alexander Khvat, Vladimir V. Kobak et al. · Tetrahedron Letters · 2004 · 32 citations

Natural Sciences, Chemistry, Organic Chemistry +5

A Novel Synthetic Smoothened Antagonist Transiently Inhibits Pancreatic Adenocarcinoma Xenografts in a Mouse Model

Martin Frank Strand, Steven Ray Wilson, Jennifer L. Dembinski et al. · PLoS ONE · 2011 · 30 citations · Full text

Medicine, Oncology, Pharmacology +14