Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Sungsoon Fang, Jae Myoung Suh, Shannon M. Reilly, +19

Nature Medicine

ObesityMetabolic SyndromeInsulin ResistanceNutritionReduces Obesity +10

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

Kihwa Kang, Shannon M. Reilly, Volkan Karabacak, +4

Cell Metabolism

ObesityMetabolic SyndromeInflammationInsulin SensitivityInsulin Signaling +11

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

Shannon M. Reilly, Shian-Huey Chiang, Stuart J. Decker, +15

Nature Medicine

ObesityMetabolic SyndromeSignal TransductionMolecular PhysiologyObesity-related Metabolic Dysfunctions +10

TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue

Peng Zhao, Kai in Wong, Xiaoli Sun, +5

Cell

InflammationMetabolic SyndromeObesityEnergy HomeostasisSignal Transduction +12

Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes

Elif A Oral, Shannon M. Reilly, Andrew V. Gomez, +19

Cell Metabolism

Metabolic SyndromeDiabetes ManagementInsulin SignalingSignal TransductionPhysiology +8

Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1

Jonathan Mowers, Maeran Uhm, Shannon M. Reilly, +5

eLife

Nfκb PathwayImmunologyRenal InflammationCell DeathCatecholamine Resistance +21

Role of Peroxisome Proliferator-activated Receptor δ/β in Hepatic Metabolic Regulation

Sihao Liu, Ben Hatano, Minghui Zhao, +8

Journal of Biological Chemistry

TANK-Binding Kinase 1 Regulates the Localization of Acyl-CoA Synthetase ACSL1 to Control Hepatic Fatty Acid Oxidation

Jin Young Huh, Shannon M. Reilly, Mohammad Abu-Odeh, +9

Cell Metabolism

Signal TransductionOxysterolBiochemistryLiver PhysiologyPhysiology +11

Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation

Wenmin Xia, Preethi Veeragandham, Yu Cao, +19

Nature Metabolism

Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1–mediated p62/sequestosome 1 phosphorylation

Chun‐Seok Cho, Hwan‐Woo Park, Allison Ho, +7

Hepatology