An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

Shannon M. Reilly, Shian-Huey Chiang, Stuart J. Decker, +15

Nature Medicine

ObesityMetabolic SyndromeSignal TransductionMolecular PhysiologyObesity-related Metabolic Dysfunctions +10

Wnt10b Inhibits Development of White and Brown Adipose Tissues

Kenneth Longo, Wendy S. Wright, Sona Kang, +5

Journal of Biological Chemistry

The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice

Shian-Huey Chiang, Merlijn Bazuine, Carey N. Lumeng, +11

Cell

ObesityMetabolic SyndromeEnergy HomeostasisEnergy MetabolismMolecular Physiology +11

Fat-specific Protein 27 Regulates Storage of Triacylglycerol

Pernille Keller, John T. Petrie, Paul De Rose, +7

Journal of Biological Chemistry

ApoptosisCell DeathFsp27 FunctionOxidative StressMetabolic Syndrome +14

Lipid raft microdomain compartmentalization of TC10 is required for insulin signaling and GLUT4 translocation

Robert T. Watson, Satoshi Shigematsu, Shian-Huey Chiang, +5

The Journal of Cell Biology

Wnt10b Inhibits Obesity in <i>ob/ob</i> and Agouti Mice

Wendy S. Wright, Kenneth Longo, Vernon W. Dolinsky, +9

Diabetes

Fabp4 PromoterMetabolic DisorderGeneticsAdipokinesInsulin Signaling +18

LXRβ Is Required for Adipocyte Growth, Glucose Homeostasis, and β Cell Function

Isabelle Gerin, Vernon W. Dolinsky, Jonathan G. Shackman, +6

Journal of Biological Chemistry

The sorbin homology domain: A motif for the targeting of proteins to lipid rafts

Akiko Kimura, Christian A. Baumann, Shian-Huey Chiang, +1

Proceedings of the National Academy of Sciences

Proteinlipid InteractionProtein AssemblySorbin Homology DomainMolecular BiologyCap Gene +16

Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1

Jonathan Mowers, Maeran Uhm, Shannon M. Reilly, +5

eLife

Nfκb PathwayImmunologyRenal InflammationCell DeathCatecholamine Resistance +21

Bone marrow–specific Cap gene deletion protects against high-fat diet–induced insulin resistance

Lisa A. Lesniewski, Sarah E. Hosch, Jaap G. Neels, +7

Nature Medicine

Metabolic SyndromeMetabolic DisorderDiabetesImmunologyMetabolic Regulation +3